Newland J C, Cooney M K
Infect Immun. 1978 Jul;21(1):303-9. doi: 10.1128/iai.21.1.303-309.1978.
Although adneovirus type 19 (Ad19) was first described in 1955, this virus was not associated with disease until its isolation from outbreaks of conjunctivitis in 1973. A strain of Ad19 isolated from a case of conjunctivitis in Seattle in 1974 was compared with the reference strain (3911). Plaque number and size were enhanced by 30 mM MgCl2. Low pH and chloroform treatment had no effect on either strain's activity, but the two strains were sensitive to pH 8. Growth curves were characteristic of adenoviruses, but differences were seen in the amount of virus released. The ratios of particles to plaque-forming units (approximately 10,000:1) were similar for both. Both virus preparations contained high concentrations of group-specific complement-fixing antigen. Cross-reactions were seen by hemagglutination inhibition and immunoelectron microscopy between antisera to Ad8, Ad9, and Ad10 versus both strains of Ad19, but were not seen by neutralization. We would like to suggest, based on exclusive conjunctivitis association and cross-reactions, that the four cross-reacting serotypes, Ad8, Ad9, Ad10, and Ad19, represent a subgroup of adenoviruses specfically associated with conjunctivitis.
虽然19型腺病毒（Ad19）于1955年首次被描述，但直到1973年从结膜炎暴发中分离出来，这种病毒才被认为与疾病有关。1974年从西雅图一例结膜炎病例中分离出的一株Ad19与参考菌株（3911）进行了比较。30 mM MgCl2可增加噬斑数量和大小。低pH值和氯仿处理对两种菌株的活性均无影响，但两种菌株对pH 8敏感。生长曲线具有腺病毒的特征，但在释放的病毒量上存在差异。两种病毒的颗粒与噬斑形成单位的比率（约10,000:1）相似。两种病毒制剂均含有高浓度的群特异性补体结合抗原。Ad8、Ad9和Ad10抗血清与两种Ad19菌株之间通过血凝抑制和免疫电子显微镜观察到交叉反应，但中和试验未观察到交叉反应。基于与结膜炎的唯一关联和交叉反应，我们认为四种交叉反应血清型Ad8、Ad9、Ad10和Ad19代表了一组与结膜炎特别相关的腺病毒亚群。
