Wadell G, de Jong J C
Infect Immun. 1980 Feb;27(2):292-6. doi: 10.1128/iai.27.2.292-296.1980.
Adenovirus type 19 (Ad19) was first associated with disease in 1973 when several outbreaks of keratoconjunctivitis were reported from Europe and North America. We have examined Ad19 isolates by deoxyribonucleic acid restriction with BamHI, BglI, and SmaI restriction endonucleases. All keratoconjunctivitis-associated Ad19 isolates were identical but different from the Ad19 prototype. The total number of resolved restriction fragments of the Ad19 prototype genome was 31, only 17 of which migrated as the restriction fragments of keratoconjunctivitis-associated genomes. We conclude that two different genome types of Ad19 exist, one of which has been responsible for the recent outbreaks of keratoconjunctivitis.
19型腺病毒（Ad19）于1973年首次与疾病相关联，当时欧洲和北美报告了几起角膜结膜炎疫情。我们用BamHI、BglI和SmaI限制性内切酶通过脱氧核糖核酸限制分析对Ad19分离株进行了检测。所有与角膜结膜炎相关的Ad19分离株都相同，但与Ad19原型不同。Ad19原型基因组的限制性片段总数为31个，其中只有17个的迁移情况与角膜结膜炎相关基因组的限制性片段相同。我们得出结论，存在两种不同基因组类型的Ad19，其中一种是近期角膜结膜炎疫情的病因。
