Stevens R H, Brooks G P, Osborne J W, White D W, Lawson A J
Immunol Commun. 1978;7(3):281-93. doi: 10.3109/08820137809025473.
Cytotoxic peripheral blood lymphoid cells were demonstrated in both Holtzman and Lewis Brown-Norway rats which had received 2000R of local X-irradiation to the temporarily hypoxic, exteriorized, ileum and jejunum regardless of whether a small bowel adenocarcinoma subsequently developed. The cytotoxic response, which was detectable at two days, was quite evident by day 5 post-irradiation. No evidence of cross-reacting tumor antigens was obtained when similarly processed effector cells from Holtzman rats bearing a spontaneous mammary carcinoma were incubated with cell cultures derived from the small bowel adenocarcinoma. These findings indicate X-irradiation of the small bowel initiates lymphocyte sensitization that is manifested as in vitro cytotoxicity against cell cultures of the adenocarcinoma.
在接受了2000伦琴局部X射线照射的霍尔兹曼大鼠和刘易斯-布朗-挪威大鼠中，均发现了细胞毒性外周血淋巴细胞，照射部位为暂时缺氧、外置的回肠和空肠，无论随后是否发生小肠腺癌。细胞毒性反应在照射后两天即可检测到，在照射后第5天非常明显。当将患有自发性乳腺癌的霍尔兹曼大鼠经类似处理的效应细胞与源自小肠腺癌的细胞培养物一起孵育时，未获得交叉反应肿瘤抗原的证据。这些发现表明，小肠的X射线照射引发淋巴细胞致敏，表现为对腺癌细胞培养物的体外细胞毒性。
