Beauchamp M L, Wolf G T
Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor.
Head Neck Surg. 1988 Jan-Feb;10(3):187-94. doi: 10.1002/hed.2890100307.
Impaired cell-mediated immunity has been consistently associated with head and neck squamous carcinoma (HNSC). Previous work has implicated monocytes in this impairment. The present study shows that in a subgroup of untreated patients with advanced HNSC, monocytes are responsible for impaired in vitro lymphokine (leukocyte migration inhibitory factor) production. In view of recent studies suggesting interactions between lymphokines and monocytes in the immune response, the present findings may be relevant to future immunotherapeutic approaches.
细胞介导的免疫功能受损一直与头颈部鳞状细胞癌（HNSC）相关。先前的研究表明单核细胞与这种免疫功能受损有关。本研究表明，在一组未经治疗的晚期HNSC患者中，单核细胞是体外淋巴因子（白细胞迁移抑制因子）产生受损的原因。鉴于最近的研究表明淋巴因子与单核细胞在免疫反应中存在相互作用，本研究结果可能与未来的免疫治疗方法相关。
