Kowalczyk D, Ruggiero I, Zembala M
J Clin Lab Immunol. 1986 Jan;19(1):37-41.
The effect of monocytes from patients with gastric cancer on lymphokine production was investigated. Patients' monocytes both augmented and reduced production of T-cell migration inhibitory factor (TIF) by normal and patients' T lymphocytes stimulated with PHA, while normal monocytes did not change or decreased the TIF production. This regulatory effect of cancer patients' monocytes on lymphokine production was independent of the initial potential of T cells to produce TIF. These observations suggest that the regulation of lymphokine production by monocytes is altered in some cancer patients.
研究了胃癌患者单核细胞对淋巴因子产生的影响。患者的单核细胞既能增强也能降低正常人和患者经PHA刺激的T淋巴细胞产生T细胞迁移抑制因子（TIF）的能力，而正常单核细胞则不会改变或降低TIF的产生。癌症患者单核细胞对淋巴因子产生的这种调节作用与T细胞产生TIF的初始潜能无关。这些观察结果表明，某些癌症患者单核细胞对淋巴因子产生的调节发生了改变。
