Vaziri N, Yousefi S, Chiu J, Li J, Carandang G, Stephenson J, Cesario T
Department of Medicine, University of California, Irvine.
J Interferon Res. 1987 Aug;7(4):389-95. doi: 10.1089/jir.1987.7.389.
Previous reports have documented that cyclosporin A (CsA) can inhibit the production of interferon-gamma (HuIFN-gamma) and interleukin-2 (IL-2). In this report we have extended these earlier findings and have demonstrated that the defect in the production of HuIFN-gamma persists even after the CsA is removed and is associated with altered synthesis of other lymphokines, mainly a cytotoxin and leukocyte migration inhibition factor. In the presence of recombinant exogenous IL-2, the effect of CsA on the synthesis of HuIFN-gamma can be reversed depending on the concentrations of both the IL-2 and CsA. In addition, the presence of the calcium ionophore A23187 partially reverses the inhibitory effect of CsA by synergistically enhancing the synthesis of HuIFN-gamma.
先前的报告已证明环孢素A（CsA）可抑制干扰素-γ（HuIFN-γ）和白细胞介素-2（IL-2）的产生。在本报告中，我们扩展了这些早期发现，并证明即使去除CsA后，HuIFN-γ产生的缺陷仍然存在，且与其他淋巴因子合成的改变有关，主要是一种细胞毒素和白细胞迁移抑制因子。在重组外源性IL-2存在的情况下，CsA对HuIFN-γ合成的影响可根据IL-2和CsA的浓度而逆转。此外，钙离子载体A23187的存在通过协同增强HuIFN-γ的合成部分逆转了CsA的抑制作用。
