南非人类免疫缺陷病毒感染者中生殖支原体感染的流行情况和耐药性：一项前瞻性队列研究。
Prevalence and Antimicrobial Resistance of Mycoplasma genitalium Infection Among Women Living With Human Immunodeficiency Virus in South Africa: A Prospective Cohort Study.
机构信息
Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, United Kingdom.
Central Clinical School, Monash University, Australia.
出版信息
Clin Infect Dis. 2019 Aug 16;69(5):873-876. doi: 10.1093/cid/ciz045.
This prospective cohort study of 622 women living with human immunodeficiency virus (HIV) from Johannesburg (2012) detected Mycoplasma genitalium in 7.4% (95% confidence interval [CI]: 5.5-9.7, 46/622), with detection more likely with lower CD4 counts(adjusted odds ratio [AOR] 1.02 per 10 cells/μL decrease, 95% CI: 1.00-1.03) and higher plasma HIV-1 RNA (AOR 1.15 per log copies/mL increase, 95% CI: 1.03-1.27). No mutations for macrolide/quinolone resistance was detected.
本研究前瞻性纳入了 622 名居住在约翰内斯堡的 HIV 感染者（2012 年），结果发现 7.4%（95%CI：5.5-9.7，46/622）的患者存在生殖道支原体感染，CD4 计数越低（校正比值比 [AOR] 每降低 10 个细胞/μL 增加 1.02，95%CI：1.00-1.03）和 HIV-1 病毒载量越高（AOR 每增加 1log 拷贝/ml 增加 1.15，95%CI：1.03-1.27），生殖道支原体感染的可能性越大。未检测到大环内酯类/喹诺酮类耐药相关突变。
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