Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, United Kingdom.
Central Clinical School, Monash University, Australia.
Clin Infect Dis. 2019 Aug 16;69(5):873-876. doi: 10.1093/cid/ciz045.
This prospective cohort study of 622 women living with human immunodeficiency virus (HIV) from Johannesburg (2012) detected Mycoplasma genitalium in 7.4% (95% confidence interval [CI]: 5.5-9.7, 46/622), with detection more likely with lower CD4 counts(adjusted odds ratio [AOR] 1.02 per 10 cells/μL decrease, 95% CI: 1.00-1.03) and higher plasma HIV-1 RNA (AOR 1.15 per log copies/mL increase, 95% CI: 1.03-1.27). No mutations for macrolide/quinolone resistance was detected.
本研究前瞻性纳入了 622 名居住在约翰内斯堡的 HIV 感染者（2012 年），结果发现 7.4%（95%CI：5.5-9.7，46/622）的患者存在生殖道支原体感染，CD4 计数越低（校正比值比 [AOR] 每降低 10 个细胞/μL 增加 1.02，95%CI：1.00-1.03）和 HIV-1 病毒载量越高（AOR 每增加 1log 拷贝/ml 增加 1.15，95%CI：1.03-1.27），生殖道支原体感染的可能性越大。未检测到大环内酯类/喹诺酮类耐药相关突变。
