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阿拉巴马州 HIV 感染男男性行为者中解脲支原体耐药率较高。

High Prevalence of Multidrug-Resistant Mycoplasma genitalium in Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in Alabama.

机构信息

Department of Medicine, Divisions of Infectious Diseases, University of Alabama at Birmingham.

Department of Pathology, University of Alabama at Birmingham.

出版信息

Clin Infect Dis. 2018 Feb 10;66(5):796-798. doi: 10.1093/cid/cix853.

DOI:10.1093/cid/cix853
PMID:29028993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5850425/
Abstract

We tested for Mycoplasma genitalium in 157 HIV-infected men. Urogenital and rectal prevalence were 10.8% and 6.4%. Macrolide resistance mutations were detected in 70.6% and 80% of urogenital and rectal samples, and fluoroquinolone resistance mutations in 26.7% and 40%, respectively.

摘要

我们在 157 名感染 HIV 的男性中检测了生殖支原体。泌尿生殖道和直肠的患病率分别为 10.8%和 6.4%。泌尿生殖道和直肠样本中分别检测到 70.6%和 80%的大环内酯类耐药突变，以及 26.7%和 40%的氟喹诺酮类耐药突变。

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High Macrolide Resistance in Mycoplasma genitalium Strains Causing Infection in Auckland, New Zealand.在新西兰奥克兰引起感染的生殖支原体菌株中存在高大环内酯耐药性。
J Clin Microbiol. 2017 Jul;55(7):2280-2282. doi: 10.1128/JCM.00370-17. Epub 2017 May 3.
2
Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium.生殖支原体对大环内酯类和氟喹诺酮类药物的耐药性不断增加。
Emerg Infect Dis. 2017 May;23(5):809-812. doi: 10.3201/eid2305.161745.
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Prevalence of macrolide and fluoroquinolone resistance-mediating mutations in Mycoplasma genitalium in five cities in Russia and Estonia.俄罗斯和爱沙尼亚五个城市生殖支原体中大环内酯类和氟喹诺酮类耐药介导突变的流行情况。
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Meta-analysis of the efficacy of moxifloxacin in treating Mycoplasma genitalium infection.莫西沙星治疗生殖支原体感染疗效的荟萃分析。
Int J STD AIDS. 2017 Oct;28(11):1106-1114. doi: 10.1177/0956462416688562. Epub 2017 Jan 24.
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Azithromycin 1.5g Over 5 Days Compared to 1g Single Dose in Urethral Mycoplasma genitalium: Impact on Treatment Outcome and Resistance.阿奇霉素 1.5g 连用 5 天与单次 1g 剂量治疗尿道解脲支原体感染：对治疗结局和耐药性的影响。
Clin Infect Dis. 2017 Feb 1;64(3):250-256. doi: 10.1093/cid/ciw719. Epub 2016 Oct 24.
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