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高剂量异烟肼在海地耐多药结核病治疗中的改善结局。

Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti.

机构信息

Center for Global Health, Weill Cornell Medicine, New York City, New York.

The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Haiti.

出版信息

Clin Infect Dis. 2019 Aug 1;69(4):717-719. doi: 10.1093/cid/ciz039.

DOI:10.1093/cid/ciz039
PMID:30698688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7322692/
Abstract

We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.

摘要

我们报告了在海地接受高剂量异烟肼治疗的耐多药结核病患者队列的结果。尽管存在高水平异烟肼耐药性，但接受高剂量异烟肼治疗的患者培养转换时间更快，成功结局的可能性更高。这表明高剂量异烟肼即使存在表型耐药性也可能具有疗效。

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本文引用的文献

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Intermediate Susceptibility Dose-Dependent Breakpoints For High-Dose Rifampin, Isoniazid, and Pyrazinamide Treatment in Multidrug-Resistant Tuberculosis Programs.耐多药结核病项目中高剂量利福平、异烟肼和吡嗪酰胺治疗的中敏剂量依赖性折点。
Clin Infect Dis. 2018 Nov 13;67(11):1743-1749. doi: 10.1093/cid/ciy346.
2
Rationale for high-dose isoniazid in the treatment of multidrug-resistant tuberculosis.大剂量异烟肼治疗耐多药结核病的理论依据。
Int J Tuberc Lung Dis. 2017 Jan 1;21(1):123-124. doi: 10.5588/ijtld.16.0619.
3
Old drugs, new purpose: retooling existing drugs for optimized treatment of resistant tuberculosis.老药新用：改造现有药物以优化耐药结核病治疗。
Clin Infect Dis. 2012 Aug;55(4):572-81. doi: 10.1093/cid/cis487. Epub 2012 May 21.
4
Meta-analysis of clinical studies supports the pharmacokinetic variability hypothesis for acquired drug resistance and failure of antituberculosis therapy.临床研究的荟萃分析支持获得性耐药和抗结核治疗失败的药代动力学变异性假说。
Clin Infect Dis. 2012 Jul;55(2):169-77. doi: 10.1093/cid/cis353. Epub 2012 Mar 30.
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Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa.南非西开普省耐异烟肼结核病患者的治疗结果。
Clin Infect Dis. 2011 Aug;53(4):369-72. doi: 10.1093/cid/cir406.
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Tuberculosis drug resistance in an area of low endemicity in 2004 to 2006: semiquantitative drug susceptibility testing and genotyping.2004年至2006年低流行地区的结核病耐药性：半定量药物敏感性检测和基因分型
J Clin Microbiol. 2008 Dec;46(12):4064-7. doi: 10.1128/JCM.01114-08. Epub 2008 Oct 15.
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A randomised controlled trial of high-dose isoniazid adjuvant therapy for multidrug-resistant tuberculosis.高剂量异烟肼辅助治疗耐多药结核病的随机对照试验。
Int J Tuberc Lung Dis. 2008 Feb;12(2):139-45.