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2004年至2006年低流行地区的结核病耐药性：半定量药物敏感性检测和基因分型

Tuberculosis drug resistance in an area of low endemicity in 2004 to 2006: semiquantitative drug susceptibility testing and genotyping.

作者信息

Springer Burkhard, Calligaris-Maibach Romana C, Ritter Claudia, Böttger Erik C

机构信息

Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland.

出版信息

J Clin Microbiol. 2008 Dec;46(12):4064-7. doi: 10.1128/JCM.01114-08. Epub 2008 Oct 15.

DOI:10.1128/JCM.01114-08
PMID:18923010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2593253/
Abstract

We determined the quantitative levels and the genetic mechanisms of resistance in drug-resistant clinical isolates of Mycobacterium tuberculosis sampled over a period of 3 years (n = 45; 17 of the isolate were multidrug resistant). Our results led us to hypothesize that some strains categorized as resistant to isoniazid, ethambutol, or streptomycin by standard laboratory procedures of in vitro drug susceptibility testing may still respond to a treatment regimen that includes these agents.

摘要

我们测定了在3年时间内采集的结核分枝杆菌耐药临床分离株的耐药定量水平和遗传机制（n = 45；其中17株为多重耐药）。我们的结果使我们推测，一些通过体外药敏试验的标准实验室程序被归类为对异烟肼、乙胺丁醇或链霉素耐药的菌株，可能仍会对包含这些药物的治疗方案产生反应。

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本文引用的文献

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Tuberculosis: drug resistance, fitness, and strategies for global control.结核病：耐药性、适应性及全球控制策略
Eur J Pediatr. 2008 Feb;167(2):141-8. doi: 10.1007/s00431-007-0606-9. Epub 2007 Nov 7.
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Genotype MTBDRplus: a further step toward rapid identification of drug-resistant Mycobacterium tuberculosis.基因型MTBDRplus：迈向快速鉴定耐药结核分枝杆菌的又一步。
J Clin Microbiol. 2008 Jan;46(1):393-4. doi: 10.1128/JCM.01066-07. Epub 2007 Oct 31.
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Impact of extensive drug resistance on treatment outcomes in non-HIV-infected patients with multidrug-resistant tuberculosis.广泛耐药对非HIV感染的耐多药结核病患者治疗结局的影响。
Clin Infect Dis. 2007 Nov 15;45(10):1290-5. doi: 10.1086/522537. Epub 2007 Oct 15.
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Evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility testing of Mycobacterium tuberculosis strains and clinical specimens.用于结核分枝杆菌菌株和临床标本利福平及异烟肼药敏试验的GenoType MTBDRplus检测方法的评估
J Clin Microbiol. 2007 Aug;45(8):2635-40. doi: 10.1128/JCM.00521-07. Epub 2007 May 30.
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Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs--worldwide, 2000-2004.2000 - 2004年全球范围内对二线药物具有广泛耐药性的结核分枝杆菌的出现
MMWR Morb Mortal Wkly Rep. 2006 Mar 24;55(11):301-5.
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Ethambutol resistance testing by mutation detection.通过突变检测进行乙胺丁醇耐药性检测。
Int J Tuberc Lung Dis. 2006 Jan;10(1):68-73.
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Multicenter evaluation of ethambutol susceptibility testing of mycobacterium tuberculosis by agar proportion and radiometric methods.采用琼脂比例法和放射测量法对结核分枝杆菌乙胺丁醇药敏试验进行多中心评估。
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