2004年至2006年低流行地区的结核病耐药性：半定量药物敏感性检测和基因分型
Tuberculosis drug resistance in an area of low endemicity in 2004 to 2006: semiquantitative drug susceptibility testing and genotyping.
作者信息
Springer Burkhard, Calligaris-Maibach Romana C, Ritter Claudia, Böttger Erik C
机构信息
Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland.
出版信息
J Clin Microbiol. 2008 Dec;46(12):4064-7. doi: 10.1128/JCM.01114-08. Epub 2008 Oct 15.
Abstract
We determined the quantitative levels and the genetic mechanisms of resistance in drug-resistant clinical isolates of Mycobacterium tuberculosis sampled over a period of 3 years (n = 45; 17 of the isolate were multidrug resistant). Our results led us to hypothesize that some strains categorized as resistant to isoniazid, ethambutol, or streptomycin by standard laboratory procedures of in vitro drug susceptibility testing may still respond to a treatment regimen that includes these agents.
摘要
我们测定了在3年时间内采集的结核分枝杆菌耐药临床分离株的耐药定量水平和遗传机制（n = 45；其中17株为多重耐药）。我们的结果使我们推测，一些通过体外药敏试验的标准实验室程序被归类为对异烟肼、乙胺丁醇或链霉素耐药的菌株，可能仍会对包含这些药物的治疗方案产生反应。
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