Department of Ophthalmology, The University of Tokyo, Bunkyo, Tokyo, Japan.
Department of Ophthalmology, Kochi Medical School, Nankoku, Kochi, Japan.
PLoS One. 2019 Jan 30;14(1):e0210362. doi: 10.1371/journal.pone.0210362. eCollection 2019.
A number of drug-releasing contact lenses are currently being studied to address issues inherent in eye drops as a drug delivery method. In this study, we developed epinastine hydrochloride-releasing daily soft contact lenses for treatment of allergic conjunctivitis and examined their in vitro and in vivo performance. Preformed soft contact lenses with/without ionic functional groups were soaked in a solution of epinastine hydrochloride in phosphate-buffered saline to prepare epinastine hydrochloride-releasing soft contact lenses. Among these contact lenses with different ionicities, anionic lenses demonstrated the maximum, relatively linear epinastine hydrochloride release, in vitro. The amount of epinastine hydrochloride release was directly proportional to the concentration of the epinastine hydrochloride solution used to prepare the contact lens. The epinastine hydrochloride-releasing anionic soft contact lens also demonstrated prolonged drug release and significantly greater efficacy compared with epinastine hydrochloride eye drops 12 h after treatment, in vivo. Further studies are required to determine the appropriate amount of epinastine hydrochloride to be contained in the anionic soft contact lenses.
目前，有许多释放药物的隐形眼镜正在被研究，以解决滴眼剂作为药物递送方法所固有的问题。在这项研究中，我们开发了盐酸依匹斯汀释放的日戴软性隐形眼镜，用于治疗过敏性结膜炎，并考察了其体外和体内性能。具有/不具有离子官能团的预成型软性隐形眼镜浸泡在盐酸依匹斯汀的磷酸盐缓冲盐溶液中，制备盐酸依匹斯汀释放软性隐形眼镜。在这些具有不同离子特性的隐形眼镜中，阴离子镜片在体外表现出最大的、相对线性的盐酸依匹斯汀释放。盐酸依匹斯汀释放量与用于制备隐形眼镜的盐酸依匹斯汀溶液的浓度成正比。与盐酸依匹斯汀滴眼液相比，体内治疗 12 小时后，释放盐酸依匹斯汀的阴离子软性隐形眼镜还表现出更长的药物释放和显著更高的疗效。需要进一步研究确定阴离子软性隐形眼镜中应包含的盐酸依匹斯汀的适当含量。
