Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
J Control Release. 2018 Jul 10;281:97-118. doi: 10.1016/j.jconrel.2018.05.020. Epub 2018 May 18.
With the prevalence of electronic devices and an aging population, the number of people affected with eye disease is increasing year by year. In spite of a large number of eye drops on the market, most of them do not perform sufficiently, due to rapid clearance mechanisms and ocular barriers. To enhance drug delivery to the eye, a number of novel formulations for ocular diseases have been investigated over recent decades, aiming to increase drug retention and permeation while also allowing for sustained drug release over prolonged periods. The contact lens, initially used to correct visual acuity and beautify female eyes, is one such novel formulation with outstanding potential. Recently, contact lenses have been extensively used for ocular drug delivery to enhance ocular bioavailability and reduce side effects, and are particularly suitable for the treatment of chronic diseases, and thus are of interest to ophthalmic scientists. This review summarizes contact lens classification, methods of preparation, strategies for integrating drugs into lenses, in vitro and in vivo studies, and clinical applications. This review also discusses the current state of ocular drug therapy and provides an outlook for future therapeutic opportunities in the field of ocular drug delivery.
随着电子设备的普及和人口老龄化，眼部疾病患者的数量逐年增加。尽管市场上有大量的眼药水，但由于清除机制迅速和眼部屏障的存在，大多数眼药水的效果并不理想。为了增强药物向眼部的传递，近年来已经研究了许多用于眼部疾病的新型制剂，旨在增加药物滞留和渗透的同时，还能实现长时间的持续药物释放。隐形眼镜是一种具有巨大潜力的新型制剂，最初用于矫正视力和美化女性眼睛。最近，隐形眼镜被广泛用于眼部药物输送，以提高眼部生物利用度并减少副作用，特别适合治疗慢性疾病，因此引起了眼科科学家的兴趣。本文综述了隐形眼镜的分类、制备方法、将药物整合到镜片中的策略、体外和体内研究以及临床应用。本文还讨论了眼部药物治疗的现状，并展望了眼部药物输送领域未来的治疗机会。
