Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
Systems Molecular Oncology for Head and Neck Cancer, Seoul, Republic of Korea.
Exp Mol Med. 2019 Jan 16;51(1):1-14. doi: 10.1038/s12276-018-0202-2.
Epidermal growth factor receptor (EGFR) overexpression is common in head and neck squamous cell carcinoma. Targeted therapy specifically directed towards EGFR has been an area of keen interest in head and neck cancer research, as EGFR is potentially an integration point for convergent signaling. Despite the latest advancements in cancer diagnostics and therapeutics against EGFR, the survival rates of patients with advanced head and neck cancer remain disappointing due to anti-EGFR resistance. This review article will discuss recent multilateral efforts to discover and validate actionable strategies that involve signaling pathways in heterogenous head and neck cancer and to overcome anti-EGFR resistance in the era of precision medicine. Particularly, this review will discuss in detail the issue of cancer metabolism, which has recently emerged as a novel mechanism by which head and neck cancer may be successfully controlled according to different perspectives.
表皮生长因子受体 (EGFR) 过表达在头颈部鳞状细胞癌中很常见。针对 EGFR 的靶向治疗一直是头颈部癌症研究的热点领域，因为 EGFR 可能是汇聚信号的整合点。尽管在针对 EGFR 的癌症诊断和治疗方面取得了最新进展，但由于抗 EGFR 耐药性，晚期头颈部癌症患者的生存率仍然令人失望。本文综述了最近在发现和验证涉及头颈部癌症异质性信号通路的可操作策略以及在精准医学时代克服抗 EGFR 耐药性方面的多方努力。特别是，本文将详细讨论癌症代谢的问题，这是一个新兴的机制，根据不同的观点，头颈部癌症可能会被成功控制。
