Department of Electronic Engineering, National Chin-Yi University of Technology, Taichung, Taiwan.
Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
Sci Rep. 2019 Jan 30;9(1):984. doi: 10.1038/s41598-018-37282-3.
Today's commercial forced exercise platforms had been validated not as a well-designed rehabilitation environment for rats with a stroke, for the reason that rat with a stroke cannot take exercise at a constant intensity for a long period of time. In light of this, this work presented an adaptive, fall-free ischemic stroke rehabilitation mechanism in an animal model, which was implemented in an infrared-sensing adaptive feedback control running wheel (IAFCRW) platform. Consequently, rats with a stroke can be safely rehabilitated all the time, and particularly at full capacity for approximately one third of a training duration, in a completely fall-free environment according to individual physical differences by repeated use of an acceleration/deceleration mechanism. The performance of this platform was assessed using an animal ischemic stroke model. The IAFCRW therapy regimen was validated to outperform a treadmill and a conventional running wheel counterpart with respect to the reduction in the neurobehavioral deficits caused by middle cerebral artery occlusion (MCAo). IAFCRW is the first adaptive forced exercise training platform short of electrical stimulation-assistance in the literature, and ischemic stroke rats benefit more in terms of the behavioral tests run at the end of a 3-week rehabilitation program after a stroke thereby.
今天的商业强制运动平台尚未被验证为患有中风的大鼠的良好设计的康复环境，因为患有中风的大鼠不能长时间以恒定的强度进行运动。有鉴于此，本工作在动物模型中提出了一种自适应、无跌倒的缺血性中风康复机制，该机制在红外感应自适应反馈控制跑轮（IAFCRW）平台上实现。因此，根据个体差异，通过反复使用加速/减速机制，患有中风的大鼠可以始终在完全无跌倒的环境中安全康复，特别是在大约三分之一的训练时间内可以完全康复。使用动物缺血性中风模型评估了该平台的性能。IAFCRW 治疗方案已被验证在减轻大脑中动脉闭塞（MCAo）引起的神经行为缺陷方面优于跑步机和传统跑轮对照。IAFCRW 是文献中第一个没有电刺激辅助的自适应强制运动训练平台，患有中风的大鼠在中风后 3 周康复计划结束时进行行为测试时受益更多。
