Aksenova T A, Gorbunov V V, Tsarenok S Yu
Federal State Budgetary Educational Institution of Higher Education «Chita State Medical Academy» of the Ministry of Health of the Russian Federation, the Department of Propedeutics of Internal Diseases, Chita, Russia.
Ter Arkh. 2018 Apr 19;90(3):10-15. doi: 10.26442/terarkh201890310-15.
The aim is to study pulse wave velocity (PWV) and other parameters of arterial stiffness in patients with comorbid arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD).
32 patients with a combination of AH and COPD (group 1), 30 patients with isolated hypertension (group 2), 18 patients with isolated COPD (group 3), 30 healthy subjects (control group) were examined. Applanation tonometry and pulse wave contour analysis at the carotid-femoral segment were made by SphygmoCor (AtCor Medical).
Aortic systolic blood pressure in patients with the combination of hypertension and COPD was higher compared to the group of the patients with isolated hypertension by 9.83% (p=0.02), and the patients with COPD by 41.5% (p = 0.000042), respectively. Central pulse pressure in the first group was higher compared to the second group by 29.58% (p=0.00022), in the third group - by 53.4% (p=0.0029). The combination of hypertension and COPD (β=0.42, p=0.00019), age (β=0.39, p=0.0002) and the level of aortic pulse pressure (β=0.54, p=0.001) were marked as independent factors of PWV increasing according to the multiple regression analysis.
In patients with a combination of hypertension and COPD the increase in PWV, systolic and pulse pressure in the ascending aorta was observed, compared to patients with isolated hypertension, isolated COPD and the control group during applanation tonometry.
研究合并动脉高血压（AH）和慢性阻塞性肺疾病（COPD）患者的脉搏波速度（PWV）及其他动脉僵硬度参数。
对32例合并AH和COPD的患者（第1组）、30例单纯高血压患者（第2组）、18例单纯COPD患者（第3组）以及30例健康受试者（对照组）进行检查。采用SphygmoCor（AtCor Medical）进行压平式眼压测量及颈动脉 - 股动脉段脉搏波轮廓分析。
高血压合并COPD患者的主动脉收缩压分别比单纯高血压组高9.83%（p = 0.02），比COPD组高41.5%（p = 0.000042）。第1组的中心脉压比第2组高29.58%（p = 0.00022），比第3组高53.4%（p = 0.0029）。多元回归分析显示，高血压合并COPD（β = 0.42，p = 0.00019）、年龄（β = 0.39，p = 0.0002）和主动脉脉压水平（β = 0.54，p = 0.001）是PWV升高的独立因素。
与单纯高血压患者、单纯COPD患者及对照组相比，在压平式眼压测量过程中，高血压合并COPD患者的PWV、升主动脉收缩压和脉压均升高。
