鼠伤寒沙门氏菌中合成拟除虫菊酯的诱变活性。

Mutagenic activity in synthetic pyrethroids in Salmonella typhimurium.

作者信息

Herrera A, Laborda E

机构信息

Instituto de Edafologia y Biologia Vegetal, Madrid, Spain.

出版信息

Mutagenesis. 1988 Nov;3(6):509-14. doi: 10.1093/mutage/3.6.509.

DOI:10.1093/mutage/3.6.509

PMID:3070291

Abstract

Four pyrethroids, allethrin, resmethrin, permethrin and fenvalerate, were tested for mutagenicity in bacterial reversion assay systems with seven strains (TA1535, TA100, TA1538, TA98, TA1537, TA97 and TA104) of Salmonella typhimurium. Our results show that three pyrethroids, namely resmethrin, permethrin and fenvalerate, were not found to be mutagenic in S. typhimurium in the presence or absence of a rat liver activation system. Allethrin was found to be mutagenic with TA100, TA104 and TA97 strains and required metabolic activation (S9 mix) in order to show its activity, mainly with TA100 and TA104 strains.

摘要

选用了四种拟除虫菊酯，即丙烯菊酯、苄呋菊酯、氯菊酯和氰戊菊酯，利用鼠伤寒沙门氏菌的七个菌株（TA1535、TA100、TA1538、TA98、TA1537、TA97和TA104），通过细菌回复突变试验系统来检测其致突变性。我们的结果表明，在有或无大鼠肝脏活化系统存在的情况下，三种拟除虫菊酯，即苄呋菊酯、氯菊酯和氰戊菊酯，在鼠伤寒沙门氏菌中未发现有致突变性。发现丙烯菊酯对TA100、TA104和TA97菌株具有致突变性，并且需要代谢活化（S9混合物）才能表现出其活性，主要是对TA100和TA104菌株。