Anderson D A, Sagha H M
Biology Department, Utah State University, Logan 84322.
Mycopathologia. 1988 Dec;104(3):163-9. doi: 10.1007/BF00437432.
Cryptococcus neoformans was instilled intranasally into mice which were periodically sacrificed to determine the course of infection. Cryptococci persisted within the nasal passages throughout the 90 day study. Extranasal dissemination began 14-28 days after instillation and was still demonstrable 90 days post-exposure. Ten percent mortality was observed in mice receiving 10(6) cryptococci, while no mortality was observed in mice exposed to 10(3) or 10(4) cryptococci. Our research suggests that nasal colonization with C. neoformans can precede pulmonary and systemic cryptococcosis by weeks or months.
新型隐球菌经鼻内接种到小鼠体内，定期处死小鼠以确定感染进程。在整个90天的研究中，隐球菌在鼻腔内持续存在。鼻外播散在接种后14 - 28天开始，暴露90天后仍可检测到。接受10(6)个隐球菌的小鼠中有10%死亡，而暴露于10(3)或10(4)个隐球菌的小鼠未观察到死亡。我们的研究表明，新型隐球菌在鼻腔内定植可能比肺部和全身性隐球菌病早数周或数月。
