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新型隐球菌的假菌丝形态:体内存活率降低

Pseudohyphal forms of Cryptococcus neoformans: decreased survival in vivo.

作者信息

Neilson J B, Fromtling R A, Bulmer G S

出版信息

Mycopathologia. 1981 Jan 30;73(1):57-9. doi: 10.1007/BF00443015.

DOI:10.1007/BF00443015
PMID:7012632
Abstract

Three pseudohyphal isolates of Cryptococcus neoformans were inoculated intracranially into mice. Four weeks post-inoculation the animals showed no symptoms of disease and the number of viable cells per brain decreased to zero. Possible roles of pseudohyphal forms of C. neoformans in the immunology and pathogenesis of cryptococcosis are discussed.

摘要

将新型隐球菌的三株假菌丝分离株经颅内接种到小鼠体内。接种后四周,动物未表现出疾病症状,且每只脑内的活细胞数量降至零。文中讨论了新型隐球菌假菌丝形式在隐球菌病免疫学和发病机制中的可能作用。

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Pseudohyphal forms of Cryptococcus neoformans: decreased survival in vivo.新型隐球菌的假菌丝形态:体内存活率降低
Mycopathologia. 1981 Jan 30;73(1):57-9. doi: 10.1007/BF00443015.
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Cryptococcus neoformans: pseudohyphal forms surviving culture with Acanthamoeba polyphaga.新型隐球菌:在与多食棘阿米巴共培养后存活的假菌丝形态
Infect Immun. 1978 Apr;20(1):262-6. doi: 10.1128/iai.20.1.262-266.1978.
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Persistence of infection in mice inoculated intranasally with Cryptococcus neoformans.经鼻内接种新型隐球菌的小鼠体内感染的持续性。
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Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans.新型隐球菌的有性态——新生丝状担子菌的形态发生
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Evaluation of a fluorescent method (fluorescein diacetate and ethidium bromide solution) in the study of the viability Cryptococcus neoformans strains.
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本文引用的文献

1
Preliminary studies on a hyphaforming mutant of Cryptococcus neoformans.新型隐球菌菌丝形成突变体的初步研究。
Mycologia. 1966 May-Jun;58(3):383-90.
2
Morphological variations of a hypha-forming strain of Cryptococcus neoformans (Coward strain) in tissues of mice.新型隐球菌(考尔德菌株)菌丝形成菌株在小鼠组织中的形态学变化。
Sabouraudia. 1971 Mar;9(1):10-4. doi: 10.1080/00362177185190041.
3
Medium containing trypan blue and antibiotics for the detection of Cryptococcus neoformans in clinical samples.含有台盼蓝和抗生素的培养基,用于临床样本中新型隐球菌的检测。
“变形虫捕食者-真菌动物毒力”假说
J Fungi (Basel). 2019 Jan 21;5(1):10. doi: 10.3390/jof5010010.
4
Phenotypic Variability Correlates with Clinical Outcome in Isolates Obtained from Botswanan HIV/AIDS Patients.在来自博茨瓦纳 HIV/AIDS 患者的 中分离株中,表型变异性与临床结果相关。
mBio. 2018 Oct 23;9(5):e02016-18. doi: 10.1128/mBio.02016-18.
5
Nutritional Requirements and Their Importance for Virulence of Pathogenic Cryptococcus Species.营养需求及其对致病性隐球菌属毒力的重要性。
Microorganisms. 2017 Sep 30;5(4):65. doi: 10.3390/microorganisms5040065.
6
Cryptococcus: from environmental saprophyte to global pathogen.隐球菌:从环境腐生菌到全球病原体。
Nat Rev Microbiol. 2016 Feb;14(2):106-17. doi: 10.1038/nrmicro.2015.6. Epub 2015 Dec 21.
7
Titan cells in Cryptococcus neoformans: cells with a giant impact.新型隐球菌中的泰坦细胞:具有巨大影响的细胞。
Curr Opin Microbiol. 2013 Aug;16(4):409-13. doi: 10.1016/j.mib.2013.03.006. Epub 2013 Apr 12.
8
DNA mutations mediate microevolution between host-adapted forms of the pathogenic fungus Cryptococcus neoformans.DNA 突变介导了病原真菌新生隐球菌在宿主适应形式之间的微进化。
PLoS Pathog. 2012;8(10):e1002936. doi: 10.1371/journal.ppat.1002936. Epub 2012 Oct 4.
9
The link between morphotype transition and virulence in Cryptococcus neoformans.新型隐球菌形态转换与毒力的关系。
PLoS Pathog. 2012;8(6):e1002765. doi: 10.1371/journal.ppat.1002765. Epub 2012 Jun 21.
10
Variability of phenotypic traits in Cryptococcus varieties and species and the resulting implications for pathogenesis.表型特征在隐球菌变种和种间的变异性及其对发病机制的影响。
Future Microbiol. 2010 May;5(5):775-87. doi: 10.2217/fmb.10.44.
Appl Microbiol. 1974 Jan;27(1):38-42. doi: 10.1128/am.27.1.38-42.1974.
4
Filamentation and endogenous sporulation in Cryptococcus neoformans.
Sabouraudia. 1970 Nov;8(3):227-34.
5
Immunization of mice with an avirulent pseudohyphal form of Cryptococcus neoformans.用新型隐球菌无毒假菌丝形式对小鼠进行免疫接种。
Mycopathologia. 1979 Sep 28;68(3):179-81. doi: 10.1007/BF00578527.
6
Kinetics of lymphocyte transformation in mice immunized with viable avirulent forms of Cryptococcus neoformans.用新型隐球菌活无毒株免疫的小鼠淋巴细胞转化动力学
Infect Immun. 1979 May;24(2):449-53. doi: 10.1128/iai.24.2.449-453.1979.
7
Cryptococcus neoformans: pseudohyphal forms surviving culture with Acanthamoeba polyphaga.新型隐球菌:在与多食棘阿米巴共培养后存活的假菌丝形态
Infect Immun. 1978 Apr;20(1):262-6. doi: 10.1128/iai.20.1.262-266.1978.