Willis Erin L, Stevens Taylor L, White Gary L, Mcfarlane Dianne
Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma.
Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Comp Med. 2019 Feb 1;69(1):55-62. doi: 10.30802/AALAS-CM-18-000050. Epub 2019 Jan 31.
Cytomegalovirus (CMV) is a common chronic herpesvirus found in humans and numerous other mammalian species. In people, chronic viruses like CMV can alter overall health and immunity and pose a serious risk for those with an inadequate immune system. In addition, CMV plays an important role in animal health, and could affect the health of vulnerable populations, like endangered species. Previous studies found a high rate of CMV seropositivity among adult baboons (), and results from our laboratory revealed that baboon CMV (BaCMV) seropositivity was correlated with altered immune cell populations. In the current study, we further characterized BaCMV infection in normal, adult baboons. Analysis of blood samples from baboons (age, 6 to 26 y) revealed a low overall prevalence of detectable of BaCMV DNA, with a higher detection rate in aged baboons (older than 15 y). Furthermore, data suggest that individual baboons maintain similar rates of recurrence and levels of BaCMV shedding in saliva over time. Finally, we evaluated multiple commercially available assays for antihuman CMV IgG and IgM for use with baboon sera. Results of this study will improve our understanding of BaCMV and may be directly relevant to other closely related species.
巨细胞病毒（CMV）是一种常见的慢性疱疹病毒，存在于人类和许多其他哺乳动物物种中。在人类中，像CMV这样的慢性病毒会改变整体健康和免疫力，对免疫系统不足的人构成严重风险。此外，CMV在动物健康中起着重要作用，并可能影响濒危物种等弱势群体的健康。先前的研究发现成年狒狒中CMV血清阳性率很高（），我们实验室的结果表明狒狒巨细胞病毒（BaCMV）血清阳性与免疫细胞群体改变相关。在本研究中，我们进一步对正常成年狒狒中的BaCMV感染进行了特征描述。对狒狒（年龄6至26岁）的血液样本分析显示，可检测到的BaCMV DNA总体患病率较低，老年狒狒（15岁以上）的检测率较高。此外，数据表明随着时间推移，个体狒狒的复发率和唾液中BaCMV脱落水平保持相似。最后，我们评估了多种市售的抗人CMV IgG和IgM检测方法用于狒狒血清。本研究结果将增进我们对BaCMV的了解，并且可能与其他密切相关物种直接相关。
