来自药食同源植物蓟中的蒲公英烷型三萜。
Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum.
机构信息
College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China.
Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
出版信息
Chin J Nat Med. 2019 Jan;17(1):22-26. doi: 10.1016/S1875-5364(19)30005-6.
Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC of 2.6 and 3.8 μmol·L, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.
在 TNF-α 分泌抑制活性测定的指导下，从药用食用植物蓟的石油醚可溶部分的活性部位中分离得到了四种蒲公英烷型三萜，包括两种新化合物 22-氧代-20-蒲公英甾烷-3β,30-二醇（1）和 22α-羟基-20-蒲公英甾烷-30β,30-三醇（2）。通过光谱数据和 CD 数据分析阐明了它们的结构。在 TNF-α 分泌抑制活性测定中，化合物 1 和 2 的 IC 分别为 2.6 和 3.8 μmol·L，具有活性。此外，化合物 1 和 2 对人卵巢癌细胞（A2780）和结肠癌细胞（HCT-8）具有中等选择性细胞毒性。
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