College of Applied Arts and Science, Beijing Union University, Beijing 100191, China.
College of Applied Arts and Science, Beijing Union University, Beijing 100191, China.
Fitoterapia. 2024 Jun;175:105879. doi: 10.1016/j.fitote.2024.105879. Epub 2024 Feb 27.
Five unusual seco-nortriterpenoids, 3β-hydroxy-20,21-seco-30-nortaraxastan-20,21-dioic acid (1), 3β-hydroxy-20,21-seco-30-nortaraxastan-20-oic-21-oate (2), 3β-hydroxy-20-oxo-21,22-seco-30-nortaraxastan-22-oic acid (3), 3β-hydroxy-19-oxo-20,21-seco-29,30-nortaraxastan-21-oic acid (4) and 3β-hydroxy-19-oxo-20,21-seco-19-norlupan-21-oic acid (5) were isolated and elucidated from the anti-inflammatory activity fraction of the ethanol extract of Cirsium setosum. The structures of these compounds were established through spectroscopic methods. Preliminary biological assays showed that compounds 1-5 had significant inhibitory effect on NO production on lipopolysaccharide-stimulated RAW 264.7 cells, and compound 1 showed the strongest anti-inflammatory activity. This type of ring-opening compound is the first seco-triterpenoid structure discovered from the genus of Cirsium.
从刺儿菜的抗炎活性部位的乙醇提取物中分离并阐明了五个不寻常的五环三萜类化合物，3β-羟基-20,21-去甲-30-贝壳杉烷-20,21-二酸（1），3β-羟基-20,21-去甲-30-贝壳杉烷-20-羧酸-21-酯（2），3β-羟基-20-氧代-21,22-去甲-30-贝壳杉烷-22-羧酸（3），3β-羟基-19-氧代-20,21-去甲-29,30-贝壳杉烷-21-羧酸（4）和 3β-羟基-19-氧代-20,21-去甲-19-降葫芦烷-21-羧酸（5）。这些化合物的结构通过光谱方法确定。初步的生物学试验表明，化合物 1-5 对脂多糖刺激的 RAW 264.7 细胞中 NO 产生具有显著的抑制作用，化合物 1 表现出最强的抗炎活性。这种开环化合物是首次从蓟属植物中发现的五环三萜类结构。
