College of Applied Arts and Science, Beijing Union University, Beijing 100191, China.
J Asian Nat Prod Res. 2024 Aug;26(8):892-899. doi: 10.1080/10286020.2024.2340074. Epub 2024 Apr 10.
Two new triterpene fatty acid esters, 3-palmityloxy-12,27-cyclofriedoolean-14-en-11-ol () and 3-palmityloxy-19-hydroxyursane (), together with 3-hydroxy-11-oxo-olean-12-enyl palmitate () were isolated from the potent anti-inflammatory active fraction of the petroleum ether-soluble part of ethanol extract. Compound was found to be a rare 12,27-cyclopropane triterpenoid. Their structures were determined through spectral data analysis combined with literature reports. Furthermore, experiment, compounds - exhibited significant inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages.
从具有强大抗炎活性的乙醇提取物的石油醚可溶部分中分离得到两种新的三萜脂肪酸酯，3-棕榈酸氧基-12,27-环丙friedoolean-14-烯-11-醇（）和 3-棕榈酸氧基-19-羟基乌苏烷（），以及 3-羟基-11-氧代-olean-12-烯基棕榈酸酯（）。化合物被发现是一种罕见的 12,27-环丙烷三萜。通过光谱数据分析结合文献报道确定了它们的结构。此外，实验表明，化合物-对脂多糖激活的小鼠 RAW264.7 巨噬细胞中一氧化氮的产生具有显著的抑制作用。
