Yano Fuzuki, Itoh Masatoshi, Hirakawa Hisashi, Yamamoto Seiichi, Yoshikawa Akira, Hatazawa Jun
Department of Nuclear Medicine and Tracer Kinetics, Osaka University, Graduate School of Medicine, Osaka, Japan.
Sendai Medical Imaging Clinic (Gazo Kenshin), Sendai, Japan.
Asia Ocean J Nucl Med Biol. 2019 Winter;7(1):13-21. doi: 10.22038/AOJNMB.2018.31101.1213.
To investigate the diagnostic accuracy of positron emission mammography (PEM) and positron emission tomography/computed tomography (PET/CT) for small breast tumors of less than 20 mm in size.
The study was conducted on a total of 100 subjects (i.e., 50 patients with pathologically proven breast cancer and 50 normal cases of medical screening). The total number of tumors was 54 (mean size: 11±5.1 mm, range: 4-20 mm). The diagnostic accuracy of PEM alone, PET/CT alone, and combined PET/CT and PEM was evaluated by two nuclear medicine physicians based on visual inspection. The two groups (i.e., tumors of ≤ 10 mm and > 10-20 mm) were compared in terms of the diagnostic capability of the three modalities (PEM alone, PET/CT alone, and PET/CT+PEM).
The sensitivities of PEM alone, PET/CT alone, and combined PET/CT and PEM were 72%, 60%, and 76%, respectively. The specificities of these tests were 98%, 100%, and 98%, respectively. Furthermore, the accuracies of these diagnostic modalities were 85%, 79%, and 87%, respectively. The combined PET/CT and PEM showed significantly higher sensitivity and accuracy than PET/CT alone (P=0.005 and P=0.02, respectively). In addition, PEM demonstrated a significantly higher sensitivity than PET/CT in the ≤ 10 mm group (P=0.03); however, no difference was observed between the two modalities in the > 10 mm group in terms of sensitivity.
F-fluorodeoxyglucose PET had limited capability for the detection of small breast cancers of < 10 mm. Combined PET/CT and PEM showed higher sensitivity and accuracy, compared to PET/CT alone.
探讨正电子发射乳腺断层显像（PEM）和正电子发射断层显像/计算机断层扫描（PET/CT）对直径小于20mm的小乳腺肿瘤的诊断准确性。
共对100名受试者进行研究（即50例经病理证实的乳腺癌患者和50例医学筛查正常病例）。肿瘤总数为54个（平均大小：11±5.1mm，范围：4 - 20mm）。两名核医学医师基于视觉检查评估单独PEM、单独PET/CT以及联合PET/CT和PEM的诊断准确性。比较两组（即直径≤10mm和>10 - 20mm的肿瘤）在三种检查方式（单独PEM、单独PET/CT以及PET/CT + PEM）下的诊断能力。
单独PEM、单独PET/CT以及联合PET/CT和PEM的敏感性分别为72%、60%和76%。这些检查的特异性分别为98%、100%和98%。此外，这些诊断方式的准确性分别为85%、79%和87%。联合PET/CT和PEM的敏感性和准确性显著高于单独PET/CT（分别为P = 0.005和P = 0.02）。此外，在直径≤10mm组中，PEM的敏感性显著高于PET/CT（P = 0.03）；然而，在直径>10mm组中，两种检查方式在敏感性方面未观察到差异。
F - 氟脱氧葡萄糖PET对直径<10mm的小乳腺癌的检测能力有限。与单独PET/CT相比，联合PET/CT和PEM显示出更高的敏感性和准确性。
