School of Medicine, University of New Mexico, Albuquerque, New Mexico.
Department of Translational Research, Institut Curie, Paris, France.
Pigment Cell Melanoma Res. 2019 Jul;32(4):593-600. doi: 10.1111/pcmr.12770. Epub 2019 Feb 16.
We evaluated clinical, phenotypic, behavioral, and histopathologic variables in relationship to melanoma-specific survival by age at diagnosis among 650 population-based melanoma patients in Connecticut, with 20 years of follow-up. Only one variable, skin awareness, was significantly associated with melanoma mortality in both groups. The variables that differed between the age-groups were anatomic site, Breslow thickness, histologic subtype, mitoses, tumor-infiltrating lymphocytes (TILs), and solar elastosis. Head and neck melanoma, Breslow thickness, nodular melanoma, and solar elastosis were all significantly more likely to be associated with mortality among the older subjects; among the younger subjects, the presence of mitoses was associated with an increased probability of dying and TILs were associated with a reduced risk of mortality.
我们评估了康涅狄格州 650 名基于人群的黑色素瘤患者的临床、表型、行为和组织病理学变量与诊断时年龄的关系，这些患者的随访时间为 20 年。只有一个变量，即皮肤意识，在两组中均与黑色素瘤死亡率显著相关。年龄组之间不同的变量是解剖部位、Breslow 厚度、组织学亚型、有丝分裂、肿瘤浸润淋巴细胞（TILs）和太阳弹性组织变性。头颈部黑色素瘤、Breslow 厚度、结节性黑色素瘤和太阳弹性组织变性在老年患者中更可能与死亡率相关；在年轻患者中，有丝分裂的存在与死亡概率增加相关，而 TILs 与降低死亡率相关。
