Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Department of Physics, Khalifa University of Science and Technology (KUST), P.O. Box: 127788, Abu Dhabi, United Arab Emirates.
J Control Release. 2019 Mar 28;298:83-98. doi: 10.1016/j.jconrel.2019.01.038. Epub 2019 Jan 29.
Vitamins are a diverse group of "life nourishing" molecules that are essential for proper childhood development, and for maintaining health throughout adulthood into old age. Vitamin supplementation is an important strategy for reducing the severe and chronic effects of malnutrition in subsets of the population of the developing world. Additionally, the precise role of many vitamins in certain conditions, including cancer and cardiovascular disease, remains an area of active research, although guidelines for vitamin supplementation in otherwise adequately nourished populations remain controversial. This review describes vitamin delivery methods and techniques, focusing on the most recent advances and novel approaches. Specific attention has been given to physical methods and novel formulations for delivery with an emphasis on reporting pros and cons of each technique and highlighting future directions. Of particular interest is the potential for transdermal delivery of certain vitamins, which is an approach that may provide advantages in some populations (e.g. for vitamin D), but that still requires considerable additional research and clinical validation.
维生素是一类多样化的“生命滋养”分子，对于儿童的正常发育以及成年人在整个成年期直至老年的健康都至关重要。维生素补充是减少发展中国家人口中某些亚群严重和慢性营养不良影响的重要策略。此外，许多维生素在某些情况下（包括癌症和心血管疾病）的确切作用仍然是一个活跃的研究领域，尽管在其他方面营养充足的人群中补充维生素的指南仍存在争议。本综述描述了维生素的输送方法和技术，重点介绍了最新的进展和新方法。特别关注了物理方法和新型制剂的输送，强调了每种技术的优缺点，并突出了未来的发展方向。特别感兴趣的是某些维生素经皮输送的潜力，这种方法在某些人群（例如维生素 D）中可能具有优势，但仍需要大量的额外研究和临床验证。
