Department of Bioprocess and Biomaterial Engineering, Faculty of Pharmaceutical Sciences, State University of São Paulo (UNESP), Araraquara, Itapeva, SP, 18409-010, Brazil.
Itapeva Experimental Campus, State University of São Paulo (UNESP), Itapeva, SP, Brazil.
Sci Rep. 2022 Jul 20;12(1):12411. doi: 10.1038/s41598-022-16179-2.
Epidemiological studies show that a significant fraction of the global population presents low levels of vitamin D. In order to address this problem, one way to administer the vitamin is to incorporate it in novel drug delivery systems, such as transdermal devices. A possible substance for this purpose is cellulose, which has a long history of use in the health area. However, the application of nanostructured cellulose membranes, as local drug delivery systems, remains a challenge. To develop a crystalline nanocellulose membrane as a new tool for the release of vitamin D. A new nanostructured membrane containing nanocellulose extracted from cotton linter and vitamin D was produced using the "casting" technique. The membrane was characterized using high-resolution scanning electron microscopy (FEG-SEM) and Fourier transform infrared spectroscopy (FT-IR). The kinetics of vitamin release was quantified using molecular spectroscopy (UV-Vis). The FT-IR spectra showed the presence of all the active components in the membrane sample, without structural alterations or the formation of new bonds. The FEG-SEM images showed the presence of vitamin crystals on the surface and in the interior of the membrane. The release of vitamin D occurred in a sustained manner, obtaining 3029 IU mL of vitamin D in 60 min. The findings demonstrated that the membrane could be used for the sustained release of vitamin D. This new biomaterial has potential as a new model for vitamin supplementation in individuals with vitamin D deficiency.
流行病学研究表明，全球相当一部分人口的维生素 D 水平较低。为了解决这个问题，一种给药方式是将维生素纳入新型药物输送系统，如透皮装置。纤维素是一种可能的物质，它在健康领域已有很长的应用历史。然而，将纳米结构纤维素膜作为局部药物输送系统应用仍然是一个挑战。为了开发结晶纳米纤维素膜作为释放维生素 D 的新工具。使用“铸造”技术生产了一种含有从棉绒中提取的纳米纤维素和维生素 D 的新型纳米结构膜。使用高分辨率扫描电子显微镜（FEG-SEM）和傅里叶变换红外光谱（FT-IR）对膜进行了表征。使用分子光谱（UV-Vis）定量了维生素释放的动力学。FT-IR 光谱显示膜样品中存在所有活性成分，没有结构改变或新键的形成。FEG-SEM 图像显示维生素晶体存在于膜的表面和内部。维生素 D 的释放呈持续释放方式，在 60 分钟内获得 3029 IU mL 的维生素 D。研究结果表明，该膜可用于维生素 D 的持续释放。这种新型生物材料有望成为维生素 D 缺乏个体补充维生素的新模式。
