General / Bariatric Surgery, Mercy Hospital, 540 East-Jefferson Street, Suite 205, Iowa City, IA, 52245, USA.
University of Iowa Hospital and Clinics, Iowa City, IA, 52242, USA.
Obes Surg. 2019 Dec;29(12):3818-3823. doi: 10.1007/s11695-019-04070-5.
Laparoscopic Roux-en-Y gastric bypass (LRYGB) patients are recommended to take multiple oral vitamin supplements daily. Transdermal multivitamin patches are being advertised as an alternative for use in bariatric patients with no data to support their efficacy. The purpose of this study was to evaluate response to daily transdermal use of multivitamin patch after LRYGB and to compare them with a control group of similar patients who used oral supplements.
A retrospective review was carried out on patients who had LRYGB at a community hospital from February 2015 to February 2019. Patients who had completed preoperative and annual postoperative bariatric laboratory tests were included. They were divided into patch and pill (control) group.
Seventeen patients were included in the patch and 27 in the pill group. Patients in each group used either patch or pills for 12 months and they were 1 year post LRYGB. Fourteen patients (82.35%) in patch group and 11 patients (40.74%) in pill group had at least 1 deficiency at annual postoperative blood work (P = .0116). Vitamin D deficiency was seen in 81% patients in patch group vs 36% in the pill group (P = .0092). Statistically significant lower postoperative serum concentrations of vitamin D, B1, and B12 were seen in the patch group.
Multivitamin patch users are more likely to have vitamin D deficiency and lower serum concentration of various vitamins and minerals. Future large studies are needed on the efficacy of multivitamin patches before they can be recommended to bariatric patient population.
腹腔镜 Roux-en-Y 胃旁路术（LRYGB）患者被建议每天服用多种口服维生素补充剂。经皮多种维生素贴片作为一种替代方法正在为肥胖症患者宣传，但其疗效尚无数据支持。本研究的目的是评估 LRYGB 后每日使用经皮多种维生素贴片的反应，并将其与使用口服补充剂的类似患者的对照组进行比较。
对 2015 年 2 月至 2019 年 2 月在社区医院接受 LRYGB 的患者进行了回顾性研究。纳入完成术前和年度术后肥胖症实验室检查的患者。他们被分为贴片组和药丸（对照）组。
共纳入 17 名贴片患者和 27 名药丸组患者。每组患者均使用贴片或药丸 12 个月，且均在 LRYGB 后 1 年。在贴片组中，有 14 名患者（82.35%）至少有一种术后年度血液检查结果缺乏，而在药丸组中，有 11 名患者（40.74%）缺乏（P=0.0116）。在贴片组中，81%的患者存在维生素 D 缺乏，而在药丸组中，这一比例为 36%（P=0.0092）。在贴片组中，术后血清维生素 D、B1 和 B12 浓度显著降低。
使用多种维生素贴片的患者更有可能出现维生素 D 缺乏和各种维生素和矿物质的血清浓度降低。在推荐给肥胖症患者群体之前，需要进行关于多种维生素贴片疗效的大型未来研究。
