IVF Spain Alicante, Av. de Ansaldo, 13, 03540, Alicante, Spain.
iGLS, Alicante, Spain, C/ Britania, 7, 03540, Alacante, Spain.
Cryobiology. 2019 Apr;87:117-119. doi: 10.1016/j.cryobiol.2019.01.014. Epub 2019 Jan 30.
The purpose of this study is to present the first birth of healthy infant born following ICSI using the new permeable cryoprotectant-free sperm vitrification protocol Easy-Sperm.
A 39 years old woman and his 40 years old partner underwent egg donation treatment at IVF-Spain Alicante (Spain). Half of the mature oocytes obtained from a young and healthy donor were fertilized by ICSI, using slow-frozen spermatozoa and the other half with vitrified spermatozoa. A total of 5 blastocysts were obtained on day 5 (3 resulting from vitrified spermatozoa and 2 from frozen sperm). The best embryo, with AA quality (derived from one of the oocytes fertilized with vitrified sperm) was transferred. The woman conceived and, following a normal pregnancy, delivered a healthy boy.
To the best of our knowledge, this is the first case report of a successful pregnancy and delivery of a healthy infant from ICSI with permeable vitrified spermatozoa in an oocyte donation program with transfer on blastocyst stage.
本研究旨在介绍首例使用新的可渗透、无冷冻保护剂的精子玻璃化方案 Easy-Sperm 进行 ICSI 后出生的健康婴儿。
一名 39 岁女性和她 40 岁的伴侣在西班牙阿利坎特的 IVF-Spain（西班牙）接受了卵子捐赠治疗。从年轻健康的供体中获得的一半成熟卵子通过 ICSI 受精，使用慢速冻精法，另一半则使用玻璃化法处理的精子。第 5 天共获得 5 个囊胚（3 个来自玻璃化精子，2 个来自冷冻精子）。选择质量最佳的 AA 级胚胎（来自一个受精的卵子）进行移植。该女性受孕，随后正常妊娠并产下一名健康男婴。
据我们所知，这是首例在卵子捐赠项目中，使用可渗透的玻璃化精子进行 ICSI，并在囊胚阶段移植，成功怀孕并分娩健康婴儿的案例报告。
