糙皮侧耳酶解残渣多糖的性质及其降血脂作用研究

Characterization and anti-hyperlipidemia effects of enzymatic residue polysaccharides from Pleurotus ostreatus.

机构信息

College of Life Science, Shandong Agricultural University, Taian 271018, PR China.

Traditional Chinese Medical Hospital of Huangdao District Qingdao, Qingdao 266500, PR China.

出版信息

Int J Biol Macromol. 2019 May 15;129:316-325. doi: 10.1016/j.ijbiomac.2019.01.164. Epub 2019 Jan 29.

DOI:10.1016/j.ijbiomac.2019.01.164

PMID:30708004

Abstract

The aims of this work were to extract the enzymatic residue polysaccharides (EnRPS) from Pleurotus ostreatus and investigate the antioxidant and anti-hyperlipidemic effects on high-fat-high-cholesterol emulsion (HFHCE)-induced liver injured mice. The results revealed that EnRPS at 400 mg/kg bw showed superior liver protective effects by ameliorating the AI, lowing the hepatic MPO, FFA, ADPN, TC and TG indicators, and improving the antioxidant status by enhancing liver enzyme activities (SOD, CAT, LEP, INS and T-AOC), eliminating the MDA content, decreasing the levels of LDL-C, TC, TG, ALT, AST and ALP, and increasing the HDL-C in serum. And in addition, GC, FTIR, NMR and pathological sections were also studied. The above consequences suggested that EnRPS could be used as functional foods of oxidative stress and anti-hyperlipidemic against liver injury.

摘要

本研究旨在从糙皮侧耳中提取酶解剩余多糖（EnRPS），并研究其对高脂高胆固醇乳剂（HFHCE）诱导的肝损伤小鼠的抗氧化和抗高血脂作用。结果表明，EnRPS 以 400mg/kg bw 的剂量发挥了优异的肝脏保护作用，改善了 AI，降低了肝 MPO、FFA、ADPN、TC 和 TG 指标，并通过增强肝脏酶活性（SOD、CAT、LEP、INS 和 T-AOC）来改善抗氧化状态，消除 MDA 含量，降低 LDL-C、TC、TG、ALT、AST 和 ALP 的水平，并增加血清中的 HDL-C。此外，还进行了 GC、FTIR、NMR 和病理切片研究。上述结果表明，EnRPS 可作为抗氧化应激和抗高血脂的功能性食品，用于防治肝损伤。