College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
Int J Biol Macromol. 2019 May 15;129:281-292. doi: 10.1016/j.ijbiomac.2019.01.182. Epub 2019 Jan 29.
In the present work, we investigated the anti-hyperlipidemic, antioxidant and organic protection effects of acidic-extractable Dictyophora indusiata polysaccharides (Ac-DPS) on hyperlipidemic mice induced by high-fat emulsion. The results demonstrated that Ac-DPS had impressive abilities to mitigate oxidative stress by increasing the activities of antioxidant enzyme and reducing the contents of lipid peroxide. Moreover, lipid levels in serum were returned to normal status. Besides, Ac-DPS exhibited potential hepatic and renal protection effects reflected by decreasing serum enzyme activities, lowering TBIL, UREA and CREA levels and increasing ALB content. At the same time, histopathological observations proved protective effects of Ac-DPS on organs. Subsequently, the physical properties of polysaccharide were also investigated by HPGPC and FT-IR. The above consequences confirmed the important role of Ac-DPS as a functional food and natural medicine in the fight against oxidative stress and the prevention of hyperlipidemia.
在本工作中，我们研究了酸性可提取的齿菌多糖（Ac-DPS）对高脂乳剂诱导的高血脂小鼠的抗高血脂、抗氧化和有机保护作用。结果表明，Ac-DPS 通过提高抗氧化酶的活性和降低脂质过氧化物的含量，具有显著的减轻氧化应激的能力。此外，血清中的脂质水平恢复到正常状态。此外，Ac-DPS 表现出潜在的肝和肾保护作用，表现为血清酶活性降低、TBIL、UREA 和 CREA 水平降低以及 ALB 含量增加。同时，组织病理学观察证实了 Ac-DPS 对器官的保护作用。随后，还通过 HPGPC 和 FT-IR 研究了多糖的物理性质。上述结果证实了 Ac-DPS 作为一种功能性食品和天然药物在对抗氧化应激和预防高血脂中的重要作用。
