Department of Physiology, Federal University of Rio Grande do Sul, Campus Centro, 90050-170 Porto Alegre, Brazil; Enzymes and Biomass Laboratory, Institute of Biotechnology, University of Caxias do Sul, 95070-560 Caxias do Sul, Brazil.
Department of Physiology, Federal University of Rio Grande do Sul, Campus Centro, 90050-170 Porto Alegre, Brazil; Department of Physiology and Pharmacology, Federal University of Pelotas, Campus Capão do Leão, 96900-010 Pelotas, Brazil.
J Integr Med. 2022 Sep;20(5):385-395. doi: 10.1016/j.joim.2022.07.002. Epub 2022 Jul 11.
Mushrooms are a group of fungi with great diversity and ultra-accelerated metabolism. As a consequence, mushrooms have developed a protective mechanism consisting of high concentrations of antioxidants such as selenium, polyphenols, β-glucans, ergothioneine, various vitamins and other bioactive metabolites. The mushrooms of the Pleurotus genus have generated scientific interest due to their therapeutic properties, especially related to risk factors connected to the severity of coronavirus disease 2019 (COVID-19). In this report, we highlight the therapeutic properties of Pleurotus mushrooms that may be associated with a reduction in the severity of COVID-19: antihypertensive, antihyperlipidemic, antiatherogenic, anticholesterolemic, antioxidant, anti-inflammatory and antihyperglycemic properties. These properties may interact significantly with risk factors for COVID-19 severity, and the therapeutic potential of these mushrooms for the treatment or prevention of this disease is evident. Besides this, studies show that regular consumption of Pleurotus species mushrooms or components isolated from their tissues is beneficial for immune health. Pleurotus species mushrooms may have a role in the prevention or treatment of infectious diseases either as food supplements or as sources for pharmacological agents.
蘑菇是一组具有巨大多样性和超快新陈代谢的真菌。因此，蘑菇已经发展出一种保护机制，其中包括高浓度的抗氧化剂，如硒、多酚、β-葡聚糖、麦角硫因、各种维生素和其他生物活性代谢物。由于其治疗特性，特别是与 2019 年冠状病毒病 (COVID-19) 的严重程度相关的风险因素有关，褶裥灵芝属的蘑菇引起了科学界的兴趣。在本报告中，我们强调了灵芝蘑菇的治疗特性，这些特性可能与 COVID-19 严重程度的降低有关：降压、抗高血脂、抗动脉粥样硬化、降胆固醇、抗氧化、抗炎和降血糖特性。这些特性可能与 COVID-19 严重程度的风险因素有显著的相互作用，这些蘑菇治疗这种疾病的潜力是显而易见的。除此之外，研究表明，经常食用灵芝属蘑菇或从其组织中分离出的成分有益于免疫健康。灵芝属蘑菇可能在预防或治疗传染病方面发挥作用，无论是作为食品补充剂还是作为药物来源。
