Numonov Sodik, Sharopov Farukh, Salimov Aminjon, Sukhrobov Parviz, Atolikshoeva Sunbula, Safarzoda Ramazon, Habasi Maidina, Aisa Haji Akber
Research Institution "Chinese-Tajik Innovation Center for Natural Products" of the Tajikistan Academy of Sciences, Ayni str. 299/2, Dushanbe 734063, Tajikistan.
Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
Medicines (Basel). 2019 Jan 31;6(1):23. doi: 10.3390/medicines6010023.
Central Asia is the center of origin and diversification of the genus. The genus is known to possess a rich phytochemical diversity. Artemisinin is the shining example of a phytochemical isolated from , which is widely used in the treatment of malaria. There is great interest in the discovery of alternative sources of artemisinin in other species. The hexane extracts of plants were prepared with ultrasound-assisted extraction procedures. Silica gel was used as an adsorbent for the purification of extract. High-performance liquid chromatography with ultraviolet detection was performed for the quantification of underivatized artemisinin from hexane extracts of plants. Artemisinin was found in seven species collected from Tajikistan. Content of artemisinin ranged between 0.07% and 0.45% based on dry mass of species samples. The artemisinin contents were observed in seven species. was found to be a novel plant source of artemisinin. Purification of hexane extract using silica gel as adsorbent resulted in enrichment of artemisinin.
中亚是该属植物的起源和多样化中心。已知该属植物具有丰富的植物化学多样性。青蒿素是从该属植物中分离出的一种植物化学物质的杰出范例，它被广泛用于治疗疟疾。人们对在其他该属物种中发现青蒿素的替代来源有着浓厚兴趣。使用超声辅助提取程序制备了该属植物的己烷提取物。硅胶用作该属提取物纯化的吸附剂。采用带紫外检测的高效液相色谱法对植物己烷提取物中的未衍生化青蒿素进行定量分析。在从塔吉克斯坦采集的7种该属物种中发现了青蒿素。基于该属物种样品的干质量，青蒿素含量在0.07%至0.45%之间。在7种该属物种中观察到了青蒿素含量。发现该属是青蒿素的一种新植物来源。使用硅胶作为吸附剂对该属己烷提取物进行纯化导致青蒿素富集。
