Rîmbu Cristina Mihaela, Serbezeanu Diana, Vlad-Bubulac Tăchiță, Suflet Dana Mihaela, Motrescu Iuliana, Lungoci Constantin, Robu Teodor, Vrînceanu Narcisa, Grecu Mariana, Cozma Andreea Paula, Fotea Lenuța, Anița Dragoș Constantin, Popovici Ivona, Horhogea Cristina Elena
Department of Public Health, Iasi "Ion Ionescu de la Brad" University of Life Sciences, 8 Sadoveanu Alley, 707027 Iasi, Romania.
Department of Polycondensation and Thermally Stable Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania.
Gels. 2023 Dec 28;10(1):26. doi: 10.3390/gels10010026.
In this study, the potential use of essential oil in bio-applications was investigated. Firstly, the phytochemicals from were analyzed by different methods. Secondly, the essential oil was incorporated into the hydrogel matrix based on poly(vinyl alcohol) (PVA) and agar (A). The structural, morphological, and physical properties of the hydrogel matrix loaded with different amounts of essential oil were thoroughly investigated. FTIR analysis revealed the successful loading of the essential oil into the PVA/A hydrogel matrix. The influence of the mechanical properties and antimicrobial activity of the PVA/A hydrogel matrix loaded with different amounts of was also assessed. The antimicrobial activity of (EO ) essential oil was tested using the disk diffusion method and the time-kill assay method after entrapment in the PVA/A hydrogel matrices. The results showed that PVA/agar-based hydrogels loaded with EO exhibited significant antimicrobial activity (log reduction ratio in the range of 85.5111-100%) against nine pathogenic isolates, both Gram-positive (, , , ) and Gram-negative (, , , , and ). The resulted biocompatible polymers proved to have enhanced properties when functionalized with the essential oil of , offering opportunities and possibilities for novel applications.
在本研究中，对香精油在生物应用中的潜在用途进行了研究。首先，采用不同方法对[香精油来源]的植物化学成分进行了分析。其次，将该香精油掺入基于聚乙烯醇（PVA）和琼脂（A）的水凝胶基质中。对负载不同量香精油的水凝胶基质的结构、形态和物理性质进行了深入研究。傅里叶变换红外光谱（FTIR）分析表明香精油成功负载到PVA/A水凝胶基质中。还评估了负载不同量[香精油]的PVA/A水凝胶基质的机械性能和抗菌活性的影响。将[香精油名称缩写为EO]香精油包封在PVA/A水凝胶基质中后，采用纸片扩散法和时间杀菌试验法测试了其抗菌活性。结果表明，负载EO的基于PVA/琼脂的水凝胶对9种致病分离株具有显著的抗菌活性（对数减少率在85.5111 - 100%范围内），这些分离株包括革兰氏阳性菌（[具体菌名1]、[具体菌名2]、[具体菌名3]、[具体菌名4]）和革兰氏阴性菌（[具体菌名5]、[具体菌名6]、[具体菌名7]、[具体菌名8]、[具体菌名9]）。结果表明，用[香精油名称]香精油功能化后的生物相容性聚合物具有增强的性能，为新型应用提供了机会和可能性。
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