微小RNA与移植
MicroRNAs and Transplantation.
作者信息
Khan Zahraa, Suthanthiran Manikkam, Muthukumar Thangamani
机构信息
Division of Nephrology and Hypertension, Department of Medicine, New York-Presbyterian-Weill Cornell Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA; Division of Nephrology and Hypertension, Department of Transplantation Medicine, New York-Presbyterian-Weill Cornell Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA.
Division of Nephrology and Hypertension, Department of Medicine, New York-Presbyterian-Weill Cornell Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA; Division of Nephrology and Hypertension, Department of Transplantation Medicine, New York-Presbyterian-Weill Cornell Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA.
出版信息
Clin Lab Med. 2019 Mar;39(1):125-143. doi: 10.1016/j.cll.2018.10.003. Epub 2018 Dec 22.
miRNAs, ∼20 to 22 nucleotide single-stranded RNA species that play a pivotal role in the regulation of protein-coding genes, are emerging as robust biomarkers for assessing allograft status. Herein, the authors briefly review the biogenesis and function of the miRNAs and provide an overview of the tools to quantify miRNAs in tissues and body fluids. They then review their studies of discovery and validation of alterations in miRNA expression within kidney allografts with or without acute rejection, as well as with or without fibrosis, and summarize published data on miRNA expression patterns in kidney transplant recipients.
微小RNA（miRNA）是一类约20至22个核苷酸的单链RNA分子，在蛋白质编码基因的调控中发挥关键作用，正逐渐成为评估同种异体移植状态的可靠生物标志物。在此，作者简要回顾了miRNA的生物合成和功能，并概述了用于定量组织和体液中miRNA的工具。然后，他们回顾了自己关于发现和验证肾同种异体移植中有无急性排斥反应以及有无纤维化时miRNA表达变化的研究，并总结了已发表的肾移植受者中miRNA表达模式的数据。
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