Department of Pathology, The University of Chicago, Chicago, IL
J Exp Med. 2019 Mar 4;216(3):479-481. doi: 10.1084/jem.20181850. Epub 2019 Feb 1.
In this issue of , Gao et al. (https://doi.org/10.1084/jem.20180765) demystify the exceptional metastatic success of ovarian cancer, the most lethal female malignancy: fibroblasts form heterotypic aggregates with disseminating cancer cells, thereby providing them with reciprocal signaling and matrix for adherence.