Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada.
Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada; Department of Psychology, Université du Québec à Montréal, Montreal Quebec, Canada.
Neurobiol Aging. 2019 Apr;76:106-114. doi: 10.1016/j.neurobiolaging.2018.12.012. Epub 2019 Jan 6.
Accumulating evidence demonstrates a direct relationship between impaired neural integrity and disrupted sleep physiology in normal and pathological aging. However, previous work has focus almost exclusively on nonrapid eye movement sleep electroencephalography as a proxy of cortical integrity with aging. Whether this relationship holds true for rapid eye movement sleep electroencephalography is unknown. Our results show that age-related reduction in low-frequency delta activity during both rapid eye movement and nonrapid eye movement sleep was statistically mediated by the thinning of the medial frontal and anterior cingulate cortices. These findings (1) support the potential role of the medial frontal and cingulate cortices, major hubs of the human brain, in synchronizing neuronal assemblies during sleep, and (2) suggest that, with age, a reduction in cortical integrity within this frontal network mediates the loss of delta power during sleep. Further work will determine whether cortical thinning and delta loss may interact and contribute to cognitive decline with aging.
越来越多的证据表明，在正常和病理性衰老中，神经完整性的受损与睡眠生理学的紊乱之间存在直接关系。然而，之前的研究几乎完全集中在非快速眼动睡眠脑电图作为皮质完整性随年龄变化的替代指标。这种关系是否适用于快速眼动睡眠脑电图尚不清楚。我们的结果表明，与年龄相关的快速眼动和非快速眼动睡眠期间低频 delta 活动的减少，在统计学上与内侧额皮质和前扣带回皮质的变薄有关。这些发现 (1) 支持了内侧额皮质和扣带回皮质在睡眠期间同步神经元集合的潜在作用，这些区域是人类大脑的主要枢纽；(2) 表明随着年龄的增长，该额叶网络内皮质完整性的降低介导了睡眠期间 delta 功率的丧失。进一步的研究将确定皮质变薄和 delta 丧失是否可能相互作用并导致与年龄相关的认知能力下降。
