Weiss P, Ritz R
Abteilung für Intensivmedizin, Medizinische Universitätskliniken, Kantonsspital Basel.
Anasth Intensivther Notfallmed. 1988 Dec;23(6):309-12.
The analgetic effect and the side effects of buprenorphine (Temgesic) and morphine were compared in a double blind randomised study in 76 patients with suspected acute coronary heart disease. In 68 patients the acute coronary heart disease could be proven, in 61 patients the protocols could be entirely analysed. In 7 of 30 patients on buprenorphine and in 10 of 31 on morphine the analgetic effect was not sufficient (n.s.). The observed side effects were hypotension, bradycardia, nausea, vomiting, vertigo, reduction in respiratory rate and sedation. There were no significant differences in the rate of these side effects in the two groups. The average reduction in respiratory rate was more prominent in the buprenorphine group (-8 vs. -3/min. p less than 0.001) but we found no significant difference in both groups in the number of patient with a respiratory rate less than 12/min. We conclude that buprenorphine is safe for use in the pain therapy of patients with acute coronary heart disease and has a similar analgetic effect and profile of side effects as morphine. It can be used as an alternative to morphine in acute coronary heart disease.
在一项针对76例疑似急性冠心病患者的双盲随机研究中，比较了丁丙诺啡（替利定）和吗啡的镇痛效果及副作用。68例患者的急性冠心病得到证实，61例患者的方案得以全面分析。30例使用丁丙诺啡的患者中有7例、31例使用吗啡的患者中有10例镇痛效果不佳（无统计学差异）。观察到的副作用有低血压、心动过缓、恶心、呕吐、眩晕、呼吸频率降低和镇静作用。两组这些副作用的发生率无显著差异。丁丙诺啡组呼吸频率的平均降低更为显著（-8次/分钟对-3次/分钟，p<0.001），但我们发现两组中呼吸频率低于12次/分钟的患者数量无显著差异。我们得出结论，丁丙诺啡用于急性冠心病患者的疼痛治疗是安全的，其镇痛效果和副作用情况与吗啡相似。它可作为急性冠心病中吗啡的替代药物。
