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新工具检测粪便:分子诊断时代旅行者腹泻的管理。

New Tools to Test Stool: Managing Travelers' Diarrhea in the Era of Molecular Diagnostics.

机构信息

Department of Pathology and Laboratory Medicine, Division of Medical Microbiology, University of British Columbia, Vancouver General Hospital, 899 West 12th Avenue, Vancouver, British Columbia V5Z 1M9, Canada.

J.D. MacLean Centre for Tropical Diseases, McGill University Health Centre, 1001 Boulevard Decarie, Montreal, Quebec H4A 3J1, Canada.

出版信息

Infect Dis Clin North Am. 2019 Mar;33(1):197-212. doi: 10.1016/j.idc.2018.10.012.

DOI:10.1016/j.idc.2018.10.012
PMID:30712762
Abstract

Travelers' diarrhea affects up to 60% of visitors to tropical and subtropical regions. Although symptoms are generally self-limited, some infections are associated with significant morbidity and occasional mortality. Newer molecular diagnostic techniques allow for highly sensitive, specific, and expeditious testing of a wide range of potential pathogens. Identification of the causative pathogen of travelers' diarrhea allows for targeted therapy and management and a reduction in empiric broad-spectrum coverage.

摘要

旅行者腹泻影响高达 60%的热带和亚热带地区的游客。尽管症状通常是自限性的,但有些感染与显著的发病率和偶尔的死亡率有关。新的分子诊断技术可高度敏感、特异和快速地检测广泛的潜在病原体。确定旅行者腹泻的病原体可进行针对性治疗和管理,并减少经验性广谱覆盖。

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