Echeverria P, Blacklow N R, Sanford L B, Cukor G G
J Infect Dis. 1981 Jun;143(6):767-71. doi: 10.1093/infdis/143.6.767.
Diarrheal disease was studied prospectively in 35 Peace Corps volunteers during their first five weeks in rural Thailand. Twenty (57%) developed the syndrome of travelers' diarrhea. Recognized bacterial enteric pathogens were isolated from stools during 47% of 39 episodes of travelers' diarrhea. Enterotoxigenic Escherichia coli was isolated during 26% and Shigella during 13% of the episodes. Of the 20 volunteers, 50% had bacteriologic and/or serologic evidence of infection with enterotoxigenic E. coli. Sixty-one percent of isolates of enterotoxigenic E. coli and 92% of isolates of Shigella were resistant to doxycycline. Other enteric pathogens, including Campylobacter jejuni/coli, Yersinia enterocolitica, Salmonella, rotavirus, Norwalk agent, and Entamoeba histolytica, were associated with episodes of travelers' diarrhea. Aeromonas hydrophila, isolated from 31% of 39 episodes of travelers' diarrhea, was of unknown pathogenic importance. Thus, episodes of travelers' diarrhea in Thailand were associated with a variety of organisms, among which antibiotic-resistant bacterial enteropathogens were common.
对35名和平队志愿者在泰国农村的头五周进行了腹泻病的前瞻性研究。20人（57%）出现了旅行者腹泻综合征。在39例旅行者腹泻中，47%的病例从粪便中分离出了公认的细菌性肠道病原体。产肠毒素大肠杆菌在26%的病例中被分离出，志贺菌在13%的病例中被分离出。在20名志愿者中，50%有产肠毒素大肠杆菌感染的细菌学和/或血清学证据。61%的产肠毒素大肠杆菌分离株和92%的志贺菌分离株对强力霉素耐药。其他肠道病原体，包括空肠弯曲菌/结肠弯曲菌、小肠结肠炎耶尔森菌、沙门菌、轮状病毒、诺沃克病毒和溶组织内阿米巴，与旅行者腹泻发作有关。从39例旅行者腹泻中的31%分离出的嗜水气单胞菌，其致病重要性尚不清楚。因此，泰国旅行者腹泻发作与多种病原体有关，其中抗生素耐药的细菌性肠道病原体很常见。
