Djamshidian Atbin, Bernschneider-Reif Sabine, Poewe Werner, Lees Andrew J
Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies University of London London United Kingdom.
Department of Neurology Medical University Innsbruck Innsbruck Austria.
Mov Disord Clin Pract. 2015 Oct 6;3(1):19-26. doi: 10.1002/mdc3.12242. eCollection 2016 Jan-Feb.
, a liana indigenous to the Amazon basin with metagnomigenic properties and possible anti-depressant effects is one of the natural sources of harmala alkaloids. A summary of early trials with extracts of and (from which harmine was first isolated) in the 1920s and 1930s on various forms of parkinsonism is given as well as a brief overview of the known pharmacological properties of harmine. Despite its earlier abandonment because of perceived weaker efficacy than solanaceous alkaloids like scopolamine and hyoscine we propose that harmine should be reconsidered as a potential rapidly acting anti-Parkinsonian agent.
一种原产于亚马逊盆地的藤本植物，具有致幻特性和可能的抗抑郁作用，是哈尔满生物碱的天然来源之一。文中给出了20世纪20年代和30年代对[植物名称1]和[植物名称2]（从中首次分离出哈尔明）提取物针对各种帕金森病形式进行的早期试验总结，以及哈尔明已知药理特性的简要概述。尽管由于认为其疗效比东莨菪碱和海索比妥等茄科生物碱弱而较早被放弃，但我们认为哈尔明应被重新视为一种潜在的快速起效的抗帕金森病药物。
