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开窗分支腔内主动脉修复术中上肢入路的结果。

Outcomes of upper extremity access during fenestrated-branched endovascular aortic repair.

机构信息

Mayo Clinic Aortic Center, Advanced Endovascular Aortic Research Program, Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minn.

Mayo Clinic Aortic Center, Advanced Endovascular Aortic Research Program, Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minn.

出版信息

J Vasc Surg. 2019 Mar;69(3):635-643. doi: 10.1016/j.jvs.2018.05.214. Epub 2018 Oct 24.

Abstract

OBJECTIVE

Upper extremity (UE) access is frequently used during fenestrated-branched endovascular aortic repair (F-BEVAR) to facilitate catheterization of downgoing vessels. Limitations include risk of cerebral embolization and of UE arterial or peripheral nerve injury. The aim of this study was to assess outcomes of F-BEVAR using UE access.

METHODS

We reviewed the clinical data of 334 consecutive patients (74% males; mean age 75 ± 8 years) treated by F-BEVAR for thoracoabdominal aortic aneurysms or pararenal aortic aneurysms between 2007 and 2016. Patients who underwent F-BEVAR with an UE approach for catheterization of the renal and/or mesenteric arteries were included in the study. End points were technical success, mortality, and a composite of access-related complications including cerebral embolization (stroke/transient ischemic attack), peripheral nerve injury, and axillary-brachial arterial complications requiring intervention.

RESULTS

There were 243 patients (73%) treated by F-BEVAR with UE access, including 147 patients (60%) with thoracoabdominal aortic aneurysms and 96 patients (40%) with pararenal aortic aneurysms. A total of 878 renal-mesenteric arteries were incorporated by fenestrations or branches with a mean of 3.6 ± 0.8 vessels per patient. All patients had surgical exposure of the brachial artery. The left side was selected in 228 (94%) and the right side in 15 (6%). The technical success of target vessel incorporation was achieved in 99% of patients (870 of 878). Arterial closure was performed using primary repair in 213 patients (88%) or bovine patch angioplasty in 29 (12%). Patch closure was required in 13% of patients (21 of 159) treated by 10- to 12F sheaths and 8% (7 of 83) of those who had 7- to 8F sheaths (P = .19). There were six deaths (2.5%) at 30 days or within the hospital stay, none owing to access-related complications. Major access-related complication occurred in eight patients (3%), with no difference between the 10- to 12F (6 of 159 [4%]) or 7- to 8F sheaths (2 of 83 [2%]; P = .45). Two patients (1%) had transient median nerve neuropraxia, which resolved within 1 year. One patient (0.5%) required surgical evacuation of an access site hematoma. There were no UE arterial pseudoaneurysms, occlusions, or distal embolizations. Five patients (2%) had strokes (three minor, two major), occurring more frequently with right side (2 of 15 [13%]) as compared with left-sided access (3 of 228 [1%]; P = .03). After a mean follow-up of 38 ± 15 months, there were no other access-related complications or reinterventions.

CONCLUSIONS

UE arterial access with surgical exposure was associated with a low rate of complications in patients treated with F-BEVAR. Closure with patch angioplasty is frequently needed, but there were no arterial occlusions, pseudoaneurysms, or distal embolizations requiring secondary procedures.

摘要

目的

在上肢血管入路(UE)常用于分支型腔内血管修复术(F-BEVAR)中,以促进下行血管的导管插入。其局限性包括脑栓塞的风险和 UE 动脉或周围神经损伤的风险。本研究的目的是评估使用 UE 入路进行 F-BEVAR 的结果。

方法

我们回顾了 2007 年至 2016 年间接受 F-BEVAR 治疗的 334 例连续患者(74%为男性;平均年龄 75±8 岁)的临床资料。为了研究目的,我们纳入了在 F-BEVAR 中使用 UE 入路对肾和/或肠系膜动脉进行导管插入的患者。终点包括技术成功率、死亡率和包括脑栓塞(中风/短暂性脑缺血发作)、周围神经损伤和需要介入治疗的腋臂动脉并发症在内的复合血管相关并发症。

结果

有 243 例患者(73%)接受了 UE 入路的 F-BEVAR 治疗,包括 147 例(60%)胸主动脉瘤和 96 例(40%)肾周动脉瘤患者。通过开窗或分支共纳入 878 个肾-肠系膜动脉,平均每例患者 3.6±0.8 个血管。所有患者均接受了肱动脉的外科暴露。左侧选择 228 例(94%),右侧选择 15 例(6%)。目标血管合并的技术成功率为 99%(870/878 例)。213 例(88%)患者采用一期修复,29 例(12%)患者采用牛心包血管成形术进行动脉闭合。13%(21/159)接受 10-12F 鞘管治疗的患者和 8%(7/83)接受 7-8F 鞘管治疗的患者需要补片闭合(P=0.19)。术后 30 天或住院期间死亡 6 例(2.5%),均与血管入路无关。8 例患者(3%)发生主要血管相关并发症,10-12F 鞘管(6/159[4%])与 7-8F 鞘管(2/83[2%])之间无差异(P=0.45)。2 例患者(1%)出现短暂性正中神经神经病,1 年内可缓解。1 例患者(0.5%)需要手术清除入路部位血肿。无 UE 动脉假性动脉瘤、闭塞或远端栓塞。5 例患者(2%)发生中风(3 例为小中风,2 例为大中风),右侧(2/15[13%])比左侧入路(3/228[1%])更常见(P=0.03)。平均随访 38±15 个月后,无其他血管相关并发症或再次介入治疗。

结论

在接受 F-BEVAR 治疗的患者中,外科暴露的 UE 动脉入路与并发症发生率低相关。需要经常进行补片血管成形术闭合,但没有动脉闭塞、假性动脉瘤或需要二次手术的远端栓塞。

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