检测银行血单位中的尼古丁和尼古丁代谢物。
Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood.
机构信息
Department of Pathology, University of Virginia School of Medicine, Charlottesville.
Department of Pathology, Division of Transfusion Medicine, Johns Hopkins University, Baltimore, MD.
出版信息
Am J Clin Pathol. 2019 Apr 2;151(5):516-521. doi: 10.1093/ajcp/aqy176.
Abstract
OBJECTIVES
To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool.
METHODS
Segments from 105 RBC units were tested for the presence of nicotine, cotinine, or trans-3'-hydroxycotinine by liquid chromatography-tandem mass spectrometry.
RESULTS
Of the 20 (19%) units that contained detectable concentrations of nicotine, cotinine, or trans-3'-hydroxycotinine, 19 (18.1%) contained concentrations consistent with the use of a nicotine-containing product within 48 hours of specimen collection. One RBC unit contained nicotine concentrations consistent with passive exposure.
CONCLUSIONS
Chemicals from nicotine-containing products are detectable within the US RBC supply. Further investigation is needed to determine the risks of transfusion-associated exposure to nicotine and other tobacco-associated chemicals among vulnerable patient populations such as neonates.
摘要
目的
通过检测 RBC 单位中尼古丁及其代谢物的浓度，来估计健康供者群体中暴露的时点流行率。
方法
采用液相色谱-串联质谱法检测 105 个 RBC 单位中尼古丁、可替宁或反式-3'-羟基可替宁的存在情况。
结果
在 20 个（19%）含有可检测浓度尼古丁、可替宁或反式-3'-羟基可替宁的单位中，19 个（18.1%）的浓度与标本采集后 48 小时内使用含尼古丁产品一致。一个 RBC 单位中含有尼古丁的浓度与被动暴露一致。
结论
在美国的 RBC 供应中可检测到含尼古丁产品的化学物质。需要进一步研究，以确定在新生儿等脆弱患者群体中，与输血相关的尼古丁和其他与烟草相关的化学物质暴露的风险。
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