David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, New York.
J Infect Dis. 2019 Apr 8;219(Suppl_1):S30-S37. doi: 10.1093/infdis/jiy666.
Potentially pandemic strains of influenza pose an undeniable threat to human populations. Therefore, it is essential to develop better strategies to enhance vaccine design and predict parameters that identify susceptible humans. CD4 T cells are a central component of protective immunity to influenza, delivering direct effector function and potentiating responses of other lymphoid cells. Humans have highly diverse influenza-specific CD4 T-cell populations that vary in stimulation history, specificity, and functionality. These complexities constitute a formidable obstacle to predicting immune responses to pandemic strains of influenza and derivation of optimal vaccine strategies. We suggest that more precise efforts to identify and enumerate both the positive and negative contributors of immunity in the CD4 T-cell compartment will aid in both predicting susceptible hosts and in development of vaccination strategies that will poise most human subjects to respond to pandemic influenza strains with protective immune responses.
具有大流行潜力的流感株对人类构成了不可否认的威胁。因此，开发更好的策略来增强疫苗设计和预测识别易感人群的参数至关重要。CD4 T 细胞是流感保护性免疫的核心组成部分，发挥直接效应功能，并增强其他淋巴细胞的反应。人类具有高度多样化的流感特异性 CD4 T 细胞群体，其刺激史、特异性和功能各不相同。这些复杂性构成了预测对大流行流感株的免疫反应和制定最佳疫苗策略的巨大障碍。我们认为，更精确地努力识别和列举 CD4 T 细胞区室中免疫的正负贡献者，将有助于预测易感宿主，并开发使大多数人类宿主能够对大流行流感株产生保护性免疫反应的疫苗接种策略。
