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奥地利炎症性肠病患者的诊断延迟

Diagnostic delay in patients with inflammatory bowel disease in Austria.

作者信息

Novacek Gottfried, Gröchenig Hans Peter, Haas Thomas, Wenzl Heimo, Steiner Pius, Koch Robert, Feichtenschlager Thomas, Eckhardt Gerald, Mayer Andreas, Kirchgatterer Andreas, Ludwiczek Othmar, Platzer Reingard, Papay Pavol, Gartner Johanna, Fuchssteiner Harry, Miehsler Wolfgang, Peters Paul-Gerhard, Reicht Gerhard, Vogelsang Harald, Dejaco Clemens, Waldhör Thomas

机构信息

Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Department of Internal Medicine, Brothers of St. John of God Hospital, St. Veit an der Glan, Spitalgasse 26, 9300, St. Veit an der Glan, Austria.

出版信息

Wien Klin Wochenschr. 2019 Mar;131(5-6):104-112. doi: 10.1007/s00508-019-1451-3. Epub 2019 Feb 4.

Abstract

BACKGROUND

Delayed diagnosis seems to be common in inflammatory bowel diseases (IBD). The study was carried out to investigate the diagnostic delay and associated risk factors in Austrian IBD patients.

METHODS

In a multicenter cross-sectional study adult patients with IBD attending 18 Austrian outpatient clinics completed a multi-item questionnaire that recorded medical and socioeconomic characteristics. The study outcome was diagnostic delay defined as the period from symptom onset to diagnosis of IBD.

RESULTS

A total of 1286 patients (Crohn's disease 830, ulcerative colitis 435, inflammatory bowel disease unclassified 21; females 651) with a median age of 40 years (interquartile range 31-52 years) and a median disease duration of 10 years (4-18 years) were analyzed. The median diagnostic delay was 6 months (2-23 months) in Crohn's disease and 3 months (1-10 months) in ulcerative colitis (p < 0.001). In the multivariable regression analysis Crohn's disease, greater age at diagnosis and a high educational level (compared to middle degree level) were independently associated with longer diagnostic delay.

CONCLUSION

The diagnostic delay was longer in Crohn's disease than in ulcerative colitis patients and was associated with greater age at diagnosis and a higher educational level.

摘要

背景

炎症性肠病(IBD)的延迟诊断似乎很常见。本研究旨在调查奥地利IBD患者的诊断延迟情况及相关危险因素。

方法

在一项多中心横断面研究中,18家奥地利门诊诊所的成年IBD患者完成了一份多项目问卷,记录了医学和社会经济特征。研究结果为诊断延迟,定义为从症状出现到IBD诊断的时间段。

结果

共分析了1286例患者(克罗恩病830例,溃疡性结肠炎435例,未分类炎症性肠病21例;女性651例),中位年龄40岁(四分位间距31 - 52岁),中位病程10年(4 - 18年)。克罗恩病的中位诊断延迟为6个月(2 - 23个月),溃疡性结肠炎为3个月(1 - 10个月)(p < 0.001)。在多变量回归分析中,克罗恩病、诊断时年龄较大和高学历(与中等学历相比)与较长的诊断延迟独立相关。

结论

克罗恩病患者的诊断延迟比溃疡性结肠炎患者更长,且与诊断时年龄较大和高学历有关。

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