一种高效的 [Fe(TFDMAP)Cl] 催化剂，用于芳基和烷基叠氮化物的 C-H 键胺化反应。
An Effective [Fe(TFDMAP)Cl] Catalyst for C-H Bond Amination with Aryl and Alkyl Azides.
机构信息
State Key Laboratory of Synthetic Chemistry and Department of Chemistry , The University of Hong Kong , Pokfulam Road , Hong Kong , China.
Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis , Shanghai Institute of Organic Chemistry , 354 Feng Lin Road , Shanghai 200032 , China.
出版信息
Org Lett. 2019 Feb 15;21(4):895-899. doi: 10.1021/acs.orglett.8b03765. Epub 2019 Feb 4.
[Fe(TFDMAP)Cl] can efficiently catalyze intermolecular sp C-H amination using aryl azides and intramolecular sp C-H amination of alkyl azides in moderate-to-high product yields. At catalyst loading down to 1 mol %, the reactions display high chemo- and regioselectivity with broad substrate scope and are effective for late-stage functionalization of complex natural/bioactive molecules.
[Fe(TFDMAP)Cl] 可以有效地催化分子间 sp C-H 氨化反应，使用芳基叠氮化物和烷基叠氮化物的分子内 sp C-H 氨化反应，得到中等至高产率的产物。在催化剂负载量低至 1 mol%的情况下，反应表现出高化学选择性和区域选择性，具有广泛的底物范围，并可有效地对复杂天然/生物活性分子进行后期官能化。
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