细胞坏死性凋亡在癌症中的作用：一把双刃剑？

The role of necroptosis in cancer: A double-edged sword?

机构信息

National Center for Liver Cancer, Shanghai, China; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Department of General Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing, China.

出版信息

Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):259-266. doi: 10.1016/j.bbcan.2019.01.006. Epub 2019 Feb 1.

DOI:10.1016/j.bbcan.2019.01.006

PMID:30716362

Abstract

Necroptosis is a programmed, caspase-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a potential therapeutic strategy against cancer. Here, we will review the recent research progress of necroptosis in conferring anti- or pro-tumoral effects and its potential application in cancer therapy.

摘要

细胞坏死性凋亡是一种程序性的、半胱天冬酶非依赖性的细胞死亡方式，其形态学特征与细胞坏死相似。与细胞凋亡不同，细胞坏死性凋亡通过释放损伤相关分子模式而引发炎症反应。最近的研究表明，肿瘤在体内发生坏死性凋亡，并且在癌症的发生和发展过程中，坏死性凋亡具有促进或抑制肿瘤的作用。此外，诱导肿瘤细胞发生坏死性凋亡已被探索作为一种治疗癌症的潜在策略。在这里，我们将综述细胞坏死性凋亡在赋予抗肿瘤或促肿瘤效应方面的最新研究进展及其在癌症治疗中的潜在应用。