University of Massachusetts Medical School, Worcester, MA, USA; John Ware Research Group, Watertown, MA, USA.
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Osteoarthritis Cartilage. 2019 May;27(5):762-770. doi: 10.1016/j.joca.2019.01.011. Epub 2019 Feb 1.
To evaluate reliability, validity and responsiveness of KOOS-12, a 12-item short form of the 42-item Knee injury and Osteoarthritis Outcome Score (KOOS) that provides Pain, Function and Quality of Life (QOL) scale scores and a summary knee impact score.
Data from 1,392 knee osteoarthritis (OA) patients from the FORCE-TJR research cohort who completed KOOS before and 6 and 12 months after total knee replacement (TKR) were analyzed. KOOS-12 includes a pain frequency item and three items measuring pain during increasingly difficult (sitting/lying, walking, stairs) activities; function items about standing, rising from sitting, getting in/out of a car, and twisting/pivoting; and the 4-item KOOS QOL scale. Percent computable scale scores, floor and ceiling effects, internal consistency reliability, validity (scale correlations, tests of known groups validity using one-way analysis of variance (ANOVA)) and responsiveness (effect sizes, standardized response means) were compared for the KOOS-12, full-length KOOS, KOOS-PS and KOOS, JR.
Internal consistency reliability was above 0.70 for all KOOS-12 scales and ≥0.90 for the KOOS-12 Summary score. Validity and responsiveness of KOOS-12 Pain, Function and QOL scales was satisfactory and reached similar conclusions as comparable full-length KOOS scales. The KOOS-12 Summary score was most responsive in discriminating between groups who differed in global ratings of post-TKR change in physical capabilities and had the highest effect sizes and standardized response means.
KOOS-12 was a reliable and valid alternative to KOOS in TKR patients with moderate to severe OA and provided three domain-specific and summary knee impact scores with substantially reduced respondent burden.
评估 KOOS-12 的可靠性、有效性和反应度，KOOS-12 是 42 项膝关节损伤和骨关节炎结局评分（KOOS）的 12 项简短形式，提供疼痛、功能和生活质量（QOL）量表评分和综合膝关节影响评分。
对来自 FORCE-TJR 研究队列的 1392 例膝关节骨关节炎（OA）患者的数据进行了分析，这些患者在全膝关节置换（TKR）前以及 6 个月和 12 个月后完成了 KOOS 评估。KOOS-12 包括一个疼痛频率项目和三个衡量逐渐困难（坐/躺、行走、上下楼梯）活动时疼痛的项目；关于站立、从坐姿起身、上下车以及扭转/旋转的功能项目；以及 4 项 KOOS QOL 量表。计算比例得分、地板和天花板效应、内部一致性信度、有效性（量表相关性、使用方差分析（ANOVA）的单向分析的已知组有效性测试）和反应度（效应大小、标准化反应均值）比较了 KOOS-12、全长 KOOS、KOOS-PS 和 KOOS、JR。
所有 KOOS-12 量表的内部一致性信度均高于 0.70，KOOS-12 综合评分的信度均高于 0.90。KOOS-12 疼痛、功能和 QOL 量表的有效性和反应度令人满意，与可比的全长 KOOS 量表得出了相似的结论。KOOS-12 综合评分在区分 TKR 后患者在身体功能方面的整体评分变化方面最具反应性，且具有最高的效应大小和标准化反应均值。
在中重度 OA 的 TKR 患者中，KOOS-12 是 KOOS 的可靠且有效的替代方案，提供了三个具有特定领域和综合膝关节影响的评分，大大减轻了应答者的负担。
