Duan Ya-Ping, Luo Jiao-Yang, Liu Hao, Shan Li-Nan, Yang Shi-Hai, Yang Mei-Hua
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China.
Zhongguo Zhong Yao Za Zhi. 2018 Dec;43(24):4808-4816. doi: 10.19540/j.cnki.cjcmm.20180703.009.
Endogenous toxic components have become an important topic in the field of traditional Chinese medicines (TCMs). Since the endogenous toxic components in TCMs are often used as clinical effective components, the safety and effectiveness of endogenous toxic substances has become an important part of the research of TCMs. In this paper, the classification and evaluation criteria of toxic Chinese medicinal materials are described, and the analytical methods of endogenous components in TCMs are summarized and expounded base on with the techniques of chromatography, spectroscopy, immunoassay, and so on. On this basis, the problems in terms of endogenous toxic components are analyzed and discussed. This paper could provide ideas and methods for the evaluation of the validity and safety of TCMs containing endogenous toxic components.
内源性毒性成分已成为中药领域的一个重要课题。由于中药中的内源性毒性成分常被用作临床有效成分，内源性有毒物质的安全性和有效性已成为中药研究的重要组成部分。本文阐述了有毒中药材的分类和评价标准，并基于色谱、光谱、免疫分析等技术，对内源性成分的分析方法进行了总结和阐述。在此基础上，对内源性毒性成分方面的问题进行了分析和讨论。本文可为含内源性毒性成分中药的有效性和安全性评价提供思路和方法。
