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花生过敏的现行和未来治疗方法。

Current and Future Treatment of Peanut Allergy.

机构信息

Emory University School of Medicine, Atlanta, Ga.

Sagamihara National Hospital, Sagamihara, Japan.

出版信息

J Allergy Clin Immunol Pract. 2019 Feb;7(2):357-365. doi: 10.1016/j.jaip.2018.11.049.

DOI:10.1016/j.jaip.2018.11.049
PMID:30717866
Abstract

Based on productive translational research programs conducted over the last 20 years, the clinical landscape of peanut allergy is now rapidly changing. In this review, we review data from recent trials of investigational peanut oral and epicutaneous immunotherapies, explore the pipeline of novel therapies in early development, and identify future research needs and priorities.

摘要

基于过去 20 年开展的富有成效的转化研究计划,花生过敏的临床格局正在迅速改变。在这篇综述中,我们回顾了最近关于研究性花生口服和皮内免疫疗法的试验数据,探讨了早期开发的新型疗法的研发管道,并确定了未来的研究需求和重点。

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1
Current and Future Treatment of Peanut Allergy.花生过敏的现行和未来治疗方法。
J Allergy Clin Immunol Pract. 2019 Feb;7(2):357-365. doi: 10.1016/j.jaip.2018.11.049.
2
Oral Immunotherapy for Peanut Allergy.口服免疫疗法治疗花生过敏
Annu Rev Med. 2016;67:375-85. doi: 10.1146/annurev-med-061014-094943. Epub 2015 Aug 26.
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Peanut Oral Immunotherapy: State of the Art.花生口服免疫治疗:最新进展。
Immunol Allergy Clin North Am. 2020 Feb;40(1):97-110. doi: 10.1016/j.iac.2019.09.005. Epub 2019 Nov 6.
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Epicutaneous peanut patch device for the treatment of peanut allergy.经皮花生贴片装置治疗花生过敏。
Expert Rev Clin Immunol. 2019 May;15(5):449-460. doi: 10.1080/1744666X.2019.1593138. Epub 2019 Mar 27.
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Administration of a probiotic with peanut oral immunotherapy: A randomized trial.口服花生免疫治疗联合益生菌治疗:一项随机试验。
J Allergy Clin Immunol. 2015 Mar;135(3):737-44.e8. doi: 10.1016/j.jaci.2014.11.034. Epub 2015 Jan 13.
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Low dose immunotherapy in very young children to treat peanut allergy.低剂量免疫疗法用于幼儿治疗花生过敏。
Expert Rev Clin Immunol. 2016 Dec;12(12):1251-1253. doi: 10.1080/1744666X.2016.1226131. Epub 2016 Sep 12.
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Low-dose oral immunotherapy for children with anaphylactic peanut allergy in Japan.日本儿童过敏性花生过敏的低剂量口服免疫治疗。
Pediatr Allergy Immunol. 2018 Aug;29(5):512-518. doi: 10.1111/pai.12898. Epub 2018 May 10.
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Current opinion and review on peanut oral immunotherapy.关于花生口服免疫疗法的当前观点与综述
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Current Trend in Immunotherapy for Peanut Allergy.花生过敏的免疫治疗新趋势
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Pathophysiological, Cellular, and Molecular Events of the Vascular System in Anaphylaxis.过敏反应中血管系统的病理生理学、细胞和分子事件。
Front Immunol. 2022 Mar 8;13:836222. doi: 10.3389/fimmu.2022.836222. eCollection 2022.
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Oral desensitization therapy for peanut allergy induces dynamic changes in peanut-specific immune responses.口服脱敏疗法治疗花生过敏可诱导花生特异性免疫应答的动态变化。
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Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study.口服免疫治疗在 1-3 岁花生过敏儿童中的疗效和安全性(免疫耐受网络 IMPACT 试验):一项随机安慰剂对照研究。
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Incidence of anaphylaxis and accidental peanut exposure: A systematic review.过敏反应和意外花生暴露的发生率:一项系统综述。
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