Department of Gynaecology and Obstetrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China.
Department of Gynaecology and Obstetrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China
Biosci Rep. 2019 Feb 15;39(2). doi: 10.1042/BSR20181901. Print 2019 Feb 28.
Preeclampsia is an idiopathic multisystem disorder with partial genetic and immunological etiology. Several studies investigated the association between various single-nucleotide polymorphisms (SNPs) in Fas and Fas ligand (FasL) genes and the risk of preeclampsia. However, they achieved inconsistent results. Therefore, we conducted a meta-analysis by systematically searching the Cochrane Library, PubMed and Embase databases and assessed this association by calculating pooled odds ratios with 95% confidence interval to reach a more trustworthy conclusion. Subgroup analyses by genotype methods and source of controls (SOC) were also conducted. Seven citations containing nine studies were included for four SNPs (Fas -670 A/G, FasL 124A/G, FasL -844C/T, Fas -1377 G/A) in this meta-analysis. Our data suggested the G allele and genotype GG of the Fas -670 A/G polymorphism, GG genotype of the FasL 124A/G polymorphism, and TT genotype of the FasL -844C/T polymorphism increased the risk of preeclampsia. Stratification analyses by genotype methods and SOC also indicated that Fas -670 A/G polymorphism was related to increased risk for preeclampsia. In conclusion, Fas and FasL gene polymorphisms play important roles in the development of preeclampsia. Further well-designed studies in other races are needed to confirm the findings of this meta-analysis.
子痫前期是一种特发性多系统疾病，具有部分遗传和免疫学病因。一些研究调查了 Fas 和 Fas 配体 (FasL) 基因中各种单核苷酸多态性 (SNP) 与子痫前期风险之间的关系。然而，它们的结果并不一致。因此，我们通过系统地搜索 Cochrane 图书馆、PubMed 和 Embase 数据库进行了荟萃分析，并通过计算合并优势比及其 95%置信区间来评估这种关联，以得出更可信的结论。还进行了按基因型方法和对照来源 (SOC) 进行的亚组分析。这项荟萃分析共纳入了四项 SNP（Fas-670A/G、FasL124A/G、FasL-844C/T、Fas-1377G/A）的七篇参考文献中的九项研究。我们的数据表明，Fas-670A/G 多态性的 G 等位基因和 GG 基因型、FasL124A/G 多态性的 GG 基因型以及 FasL-844C/T 多态性的 TT 基因型增加了子痫前期的风险。按基因型方法和 SOC 进行的分层分析也表明 Fas-670A/G 多态性与子痫前期的风险增加有关。总之，Fas 和 FasL 基因多态性在子痫前期的发生发展中起着重要作用。需要在其他种族中进行进一步设计良好的研究来证实本荟萃分析的结果。
